荧光检测活细胞中脂肪酸β氧化途径的代谢活性。
Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells.
机构信息
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Chem Commun (Camb). 2020 Mar 10;56(20):3023-3026. doi: 10.1039/c9cc09993j.
PMID:32048639
Abstract
Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.
摘要
检测活细胞中的代谢活性有助于理解细胞机制。在这里，我们报告了一种荧光探针，可用于检测活细胞中的脂肪酸β氧化（FAO）。该探针可通过 FAO 的连续酶反应进行代谢降解，并通过荧光开启来可视化 FAO 活性。
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