三肽诱导的间充质干细胞生物力学调节刺激增殖和伤口愈合。
Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing.
机构信息
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Endocrinology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
出版信息
Chem Commun (Camb). 2020 Mar 10;56(20):3043-3046. doi: 10.1039/c9cc10043a.
We demonstrate the ability of two tripeptides to promote proliferation and modulate the mechanical properties of human mesenchymal stem cells (hMSCs). Notably, Young's modulus of peptide-treated hMSCs was found to be ∼2 fold higher compared to the control group. These peptides promoted wound healing in hMSCs, without stimulating osteogenic and adipogenic differentiation, thus showing high potential in vascular tissue engineering applications.
我们证明了两种三肽能够促进人骨髓间充质干细胞（hMSCs）的增殖并调节其力学性能。值得注意的是，与对照组相比，经肽处理的 hMSCs 的杨氏模量提高了约 2 倍。这些肽促进了 hMSCs 的伤口愈合，而不会刺激成骨和脂肪分化，因此在血管组织工程应用中具有很大的潜力。
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