Wan Yuehan, Liu Haichao, Zhang Ming, Huang Zhengxian, Zhou Han, Zhu Yue, Tao Yifan, Xie Nan, Liu Xiqiang, Hou Jinsong, Wang Cheng
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Head Neck. 2020 May;42(5):1067-1076. doi: 10.1002/hed.26104. Epub 2020 Feb 12.
Epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT-inducing transcription factors (EMT-TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT-TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT-TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta-analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT-TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67-2.23) of HNSCC. Subgroup analysis for individual EMT-TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29-2.02), SNAI1 (HR = 2.17, 95% CI = 1.63-2.88), SNAI2 (HR = 1.90, 95% CI = 1.38-2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61-4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT-TFs indicates a poor prognosis for HNSCC patients.
上皮-间质转化（EMT）在癌症进展中起关键作用，主要由几种诱导EMT的转录因子（EMT-TFs）调控，包括TWIST1、TWIST2、SNAI1、SNAI2、ZEB1和ZEB2。然而，EMT-TFs在头颈部鳞状细胞癌（HNSCC）中的预后价值仍存在争议。在科学网、科学Direct、Proquest、EMBASE、PubMed和Cochrane图书馆中检索了关于EMT-TFs在HNSCC中预后作用的研究。使用Revman 5.2软件进行荟萃分析。汇总分析表明，EMT-TFs的过表达表明HNSCC患者的总生存期（OS）较差（HR = 1.93，95%CI = 1.67-2.23）。对单个EMT-TFs的亚组分析显示，TWIST1（HR = 1.61，95%CI = 1.29-2.02）、SNAI1（HR = 2.17，95%CI = 1.63-2.88）、SNAI2（HR = 1.90，95%CI = 1.38-2.62）和ZEB1（HR = 2.70，95%CI = 1.61-4.53）的过表达与HNSCC患者较差的OS显著相关。这些发现支持了EMT-TFs过表达表明HNSCC患者预后不良的假设。
