促进子相分离开辟神经元分化之路。

Prospero Phase-Separating the Way to Neuronal Differentiation.

机构信息

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria; Medical University of Vienna, Vienna, Austria.

出版信息

Dev Cell. 2020 Feb 10;52(3):251-252. doi: 10.1016/j.devcel.2020.01.022.

DOI:10.1016/j.devcel.2020.01.022

PMID:32049033

Abstract

Drosophila neural progenitors require the transcriptional repressor Prospero to promptly establish the neuronal fate of their daughter cells to avoid tumorigenesis. In this issue of Developmental Cell, Liu et al. (2020) find that Prospero is mitotically implanted and forms liquid-like droplets mediating HP1a condensation to permanently repress its targets.

摘要

果蝇神经祖细胞需要转录抑制因子 Prospero 迅速建立其子细胞的神经元命运，以避免肿瘤发生。在本期《发育细胞》中，Liu 等人发现 Prospero 在有丝分裂过程中被植入并形成液滴样结构，介导 HP1a 凝聚，从而永久抑制其靶标。