基因如何移动：激活基因的空间重定位是由核肌动蛋白为基础的途径驱动的。

How Genes Move: Spatial Repositioning of Activated Genes Is Driven by Nuclear Actin-Based Pathway.

机构信息

Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Dev Cell. 2020 Feb 10;52(3):252-254. doi: 10.1016/j.devcel.2020.01.019.

DOI:10.1016/j.devcel.2020.01.019

PMID:32049034

Abstract

Spatial repositioning of genes in nuclear space has been extensively linked to regulation of gene expression, but the mechanisms behind this directed movement have remained uncertain. In this issue of Developmental Cell, Wang et al. (2020) describe a nuclear actin-myosin-based pathway driving the movement of activated genes to the nuclear periphery.

摘要

基因在核空间中的位置重排与基因表达的调控密切相关，但这种定向运动的机制仍不清楚。在本期《发育细胞》中，Wang 等人（2020）描述了一个由核肌动蛋白-肌球蛋白组成的途径，驱动激活的基因向核边缘移动。