• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

短期缺血对大鼠脂肪皮瓣微循环及伤口愈合的影响。

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat.

作者信息

Molnar Abel, Magyar Zsuzsanna, Nachmias David Belkin, Mann Din, Szabo Balazs, Toth Laszlo, Nemeth Norbert

机构信息

MD, Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. Technical procedures, analysis and interpretation of data, manuscript preparation.

PhD, Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. Technical procedures, analysis and interpretation of data, manuscript preparation.

出版信息

Acta Cir Bras. 2020 Feb 10;34(12):e201901203. doi: 10.1590/s0102-865020190120000003. eCollection 2020.

DOI:10.1590/s0102-865020190120000003
PMID:32049184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7011208/
Abstract

PURPOSE

Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation.

METHODS

In anesthetized rats groin flaps were formed bilaterally. In Control group the flaps were repositioned and sutured back. In Ischemia-Reperfusion (I/R) group before repositioning and suturing the flap pedicles were clamped for 60 minutes. Laser Doppler (LD) fluxmetry and temperature probes were applied on the cranial, central and caudal flap regions before/after preparation and ischemia, re-suturing, and on the 1st-3rd-5th-7th-14th postoperative days, before the final examinations and biopsies for histology.

RESULTS

Flaps' skin temperature quickly recovered after repositioning. LD values were lower in the I/R group, reaching a significant level by the 3rd postoperative day, and remained lowered till the 14th day. The magnitude of alterations differed in the flap regions. Histologically normal wound healing process was seen, except for some I/R flaps, where hypertrophized mammary glands were found.

CONCLUSIONS

Short-term ischemia could influence flap microcirculation and wound healing, and may result in hypertrophized mammary glands. Laser Doppler could be used to evaluate intra- and postoperative microcirculatory changes and may have significance in predicting complications.

摘要

目的

用于重建手术的复合皮瓣在术中和术后可能会出现灌注不足和/或缺血再灌注，影响伤口愈合。我们旨在随访缺血对脂肪皮肤皮瓣伤口愈合和微循环的影响。

方法

在麻醉的大鼠双侧形成腹股沟皮瓣。对照组将皮瓣重新定位并缝合回去。在缺血再灌注（I/R）组中，在重新定位和缝合之前，将皮瓣蒂夹闭60分钟。在制备和缺血前后、重新缝合时以及术后第1、3、5、7、14天，在最终检查和组织学活检之前，对皮瓣的头侧、中央和尾侧区域应用激光多普勒（LD）血流仪和温度探头。

结果

重新定位后皮瓣的皮肤温度迅速恢复。I/R组的LD值较低，术后第3天达到显著水平，并一直降低到第14天。皮瓣各区域的变化幅度不同。组织学上可见正常的伤口愈合过程，但一些I/R皮瓣除外，在这些皮瓣中发现了乳腺增生。

结论

短期缺血可影响皮瓣微循环和伤口愈合，并可能导致乳腺增生。激光多普勒可用于评估术中和术后的微循环变化，对预测并发症可能具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/4f1b2c11e1f5/1678-2674-acb-34-12-e201901203-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/6727c5392b7a/1678-2674-acb-34-12-e201901203-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/6601ba98b7f7/1678-2674-acb-34-12-e201901203-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/2f57e6e1c678/1678-2674-acb-34-12-e201901203-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/ea1da2d0d1e7/1678-2674-acb-34-12-e201901203-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/195e636b1b84/1678-2674-acb-34-12-e201901203-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/28793e0224ad/1678-2674-acb-34-12-e201901203-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/48bce1d43bf3/1678-2674-acb-34-12-e201901203-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/4f1b2c11e1f5/1678-2674-acb-34-12-e201901203-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/6727c5392b7a/1678-2674-acb-34-12-e201901203-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/6601ba98b7f7/1678-2674-acb-34-12-e201901203-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/2f57e6e1c678/1678-2674-acb-34-12-e201901203-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/ea1da2d0d1e7/1678-2674-acb-34-12-e201901203-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/195e636b1b84/1678-2674-acb-34-12-e201901203-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/28793e0224ad/1678-2674-acb-34-12-e201901203-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/48bce1d43bf3/1678-2674-acb-34-12-e201901203-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/555b/7011208/4f1b2c11e1f5/1678-2674-acb-34-12-e201901203-gf05.jpg

相似文献

1
Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat.短期缺血对大鼠脂肪皮瓣微循环及伤口愈合的影响。
Acta Cir Bras. 2020 Feb 10;34(12):e201901203. doi: 10.1590/s0102-865020190120000003. eCollection 2020.
2
Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion.肌皮瓣缺血再灌注大鼠模型中微循环和微观流变学参数的术中和术后评估
Acta Cir Bras. 2015 Aug;30(8):551-60. doi: 10.1590/S0102-865020150080000006.
3
Impact of groin flap ischemia-reperfusion on red blood cell micro-rheological parameters in a follow-up study on rats.腹股沟皮瓣缺血再灌注对大鼠后续研究中红细胞微观流变学参数的影响。
Clin Hemorheol Microcirc. 2021;79(2):245-255. doi: 10.3233/CH-170277.
4
Sex differences in murine myocutaneous flap revascularization.鼠的肌皮瓣再血管化的性别差异。
Wound Repair Regen. 2020 Jul;28(4):470-479. doi: 10.1111/wrr.12812. Epub 2020 May 19.
5
Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.聚脱氧核苷酸可恢复缺血皮瓣实验模型中的血流。
J Vasc Surg. 2012 Feb;55(2):479-88. doi: 10.1016/j.jvs.2011.07.083. Epub 2011 Nov 3.
6
Arterial ischemia in skin flaps: microcirculatory intravascular thrombosis.皮瓣中的动脉缺血：微循环内血管血栓形成。
Plast Reconstr Surg. 1994 Feb;93(2):375-85. doi: 10.1097/00006534-199402000-00024.
7
Skin flap closure by dermal laser soldering: a wound healing model for sutureless hypospadias repair.通过真皮激光焊接进行皮瓣闭合：一种用于无缝合尿道下裂修复的伤口愈合模型。
Urology. 1997 Aug;50(2):263-72. doi: 10.1016/S0090-4295(97)00278-1.
8
[Effects of L-arginine on the microcirculation of rat island skin flaps after ischemia- reperfusion].L-精氨酸对大鼠岛状皮瓣缺血再灌注后微循环的影响
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jul;25(7):871-3.
9
Ischemic preconditioning improves the survival of skin and myocutaneous flaps in a rat model.缺血预处理可提高大鼠模型中皮肤和肌皮瓣的存活率。
Plast Reconstr Surg. 1998 Jul;102(1):140-50; discussion 151-2. doi: 10.1097/00006534-199807000-00022.
10
Arterial blood flow and microcirculatory changes in the rat groin flap after ischemia provocation by electrical stimulation of the artery.通过电刺激动脉引发缺血后大鼠腹股沟皮瓣的动脉血流及微循环变化
Microvasc Res. 2001 Nov;62(3):243-51. doi: 10.1006/mvre.2001.2339.

引用本文的文献

1
Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies.皮肤伤口愈合：从病理生理学到当前治疗方法的最新进展
Life (Basel). 2021 Jul 7;11(7):665. doi: 10.3390/life11070665.

本文引用的文献

1
Postoperative Free-Flap Monitoring Techniques.术后游离皮瓣监测技术
Semin Plast Surg. 2019 Feb;33(1):13-16. doi: 10.1055/s-0039-1677880. Epub 2019 Mar 8.
2
Ischemia-reperfusion injury in a rat microvascular skin free flap model: A histological, genetic, and blood flow study.大鼠皮瓣游离模型中再灌注损伤的组织学、遗传学和血流研究。
PLoS One. 2018 Dec 27;13(12):e0209624. doi: 10.1371/journal.pone.0209624. eCollection 2018.
3
Blood Supply to the Integument of the Abdomen of the Rat: A Surgical Perspective.大鼠腹部皮肤的血液供应：外科视角
Plast Reconstr Surg Glob Open. 2017 Sep 11;5(9):e1454. doi: 10.1097/GOX.0000000000001454. eCollection 2017 Sep.
4
The Linkage between Breast Cancer, Hypoxia, and Adipose Tissue.乳腺癌、缺氧与脂肪组织之间的联系。
Front Oncol. 2017 Sep 25;7:211. doi: 10.3389/fonc.2017.00211. eCollection 2017.
5
Flowmetry evolution in microvascular surgery: A systematic review.微血管外科中血流测量技术的发展：一项系统综述。
J Plast Reconstr Aesthet Surg. 2017 Sep;70(9):1242-1251. doi: 10.1016/j.bjps.2017.05.010. Epub 2017 May 20.
6
Impact of groin flap ischemia-reperfusion on red blood cell micro-rheological parameters in a follow-up study on rats.腹股沟皮瓣缺血再灌注对大鼠后续研究中红细胞微观流变学参数的影响。
Clin Hemorheol Microcirc. 2021;79(2):245-255. doi: 10.3233/CH-170277.
7
Experimental Rat Skin Flap Model That Distinguishes between Venous Congestion and Arterial Ischemia: The Reverse U-Shaped Bipedicled Superficial Inferior Epigastric Artery and Venous System Flap.区分静脉淤血和动脉缺血的实验性大鼠皮瓣模型：反向U形双蒂腹壁下浅动脉和静脉系统皮瓣
Plast Reconstr Surg. 2017 Jan;139(1):79e-84e. doi: 10.1097/PRS.0000000000002900.
8
Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion.肌皮瓣缺血再灌注大鼠模型中微循环和微观流变学参数的术中和术后评估
Acta Cir Bras. 2015 Aug;30(8):551-60. doi: 10.1590/S0102-865020150080000006.
9
Post-operative monitoring of free muscle transfers by Laser Doppler Imaging: A prospective study.激光多普勒成像对游离肌肉移植术后的监测：一项前瞻性研究。
Microsurgery. 2015 Oct;35(7):528-35. doi: 10.1002/micr.22469. Epub 2015 Aug 10.
10
Identification of perioperative risk factor by laser-doppler spectroscopy after free flap perfusion in the head and neck: a prospective clinical study.头颈部游离皮瓣灌注后通过激光多普勒光谱法识别围手术期危险因素：一项前瞻性临床研究。
Microsurgery. 2014 Jul;34(5):345-51. doi: 10.1002/micr.22206. Epub 2013 Nov 15.