Department of Otolaryngology and Otoneurosurgery, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Claude Bernard University Lyon 1, Lyon, France.
Department of Biostatistics, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Claude Bernard University Lyon 1, Lyon, France.
Acta Otolaryngol. 2020 May;140(5):361-365. doi: 10.1080/00016489.2020.1717608. Epub 2020 Feb 12.
Vestibular schwannomas are among the most common intracranial tumours. Their growth is difficult to predict. To study the evolution of small and medium-sized vestibular schwannomas (VSs) and identify factors predictive of growth. This was a retrospective longitudinal study at a tertiary referral centre from January 2011 to January 2018. The inclusion criteria were radiological diagnosis of sporadic unilateral VS of stage I or II. Radiological and clinical data were analysed descriptively and by multivariate logistic regression to identify factors predictive of growth. A total of 1105 cases were discussed in multidisciplinary meetings and 336 patients were included with a mean age of 57.8 years and a mean follow-up time of 24 months. Around two thirds of these patients (62.8%) had non-progressive tumours. Factors identified as predictive of VS growth were the size at diagnosis (OR = 2.622, 95% CI, 1.50-4.66; = .001) and internal auditory canal filling (OR = 7.672; 95% CI, 4.52-13.43; < .001). Monitoring is the primary treatment modality for small or medium-sized VSs. As reported here for the first time, internal auditory canal filling is significantly associated with VS growth.
前庭神经鞘瘤是最常见的颅内肿瘤之一。其生长难以预测。本研究旨在探讨小、中型前庭神经鞘瘤（VS）的演变，并确定生长的预测因素。这是一项 2011 年 1 月至 2018 年 1 月在三级转诊中心进行的回顾性纵向研究。纳入标准为影像学诊断为单侧Ⅰ期或Ⅱ期散发性 VS。对影像学和临床数据进行描述性和多变量逻辑回归分析，以确定生长的预测因素。在多学科会议上讨论了 1105 例病例，其中 336 例患者符合条件，平均年龄为 57.8 岁，平均随访时间为 24 个月。这些患者中有近三分之二（62.8%）的肿瘤无进展。被确定为 VS 生长预测因素的因素包括诊断时的大小（OR=2.622，95%CI，1.50-4.66； = .001）和内听道充盈（OR=7.672；95%CI，4.52-13.43； < .001）。监测是小或中型 VS 的主要治疗方法。正如这里首次报道的，内听道充盈与 VS 生长显著相关。
