Clinical Epidemiology, C7-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, the Netherlands.
Clinical Epidemiology, C7-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, the Netherlands.
Thromb Res. 2020 Apr;188:44-48. doi: 10.1016/j.thromres.2020.01.021. Epub 2020 Jan 21.
The adipocyte-derived hormone leptin has been associated with altered blood coagulation in in vitro studies. However, it is unclear whether this association is relevant in vivo and to what extent this association is influenced by total body fat. Therefore, we aimed to examine the association between serum leptin and blood coagulation while taking total body fat into account in a population-based cohort study.
We performed a cross-sectional analysis with baseline measurements of 5797 participants of the Netherlands Epidemiology of Obesity (NEO) study, a population-based cohort of middle-aged men and women. We examined associations between serum leptin concentration and coagulation factor concentrations and parameters of platelet activation in linear regression analyses. All analyses were adjusted for multiple covariates, including total body fat.
In multivariable adjusted analyses a 1 μg/L higher serum leptin concentration was associated with a 0.22 IU/dL (95% CI: 0.11, 0.32) higher FVIII concentration and a 0.20 IU/dL (95% CI: 0.14, 0.27) higher FIX concentration (3.5 IU/dL FVIII and 3.2 IU/dL FIX per SD leptin). Serum leptin concentration was not associated with FXI, fibrinogen, platelet count, mean platelet volume and platelet distribution width in multivariable adjusted analyses.
This study showed that serum leptin concentration was associated with higher concentrations of FVIII and FIX in an observational study, which could be clinically relevant.
脂肪细胞衍生激素瘦素已被证实与体外研究中的血液凝固改变有关。然而，目前尚不清楚这种关联在体内是否相关，以及这种关联在多大程度上受到全身脂肪的影响。因此，我们旨在在一项基于人群的队列研究中，在考虑全身脂肪的情况下，检查血清瘦素与血液凝固之间的关系。
我们对荷兰肥胖症流行病学研究（NEO）的 5797 名参与者进行了横断面分析，该研究是一项基于人群的中年男女队列研究。我们在线性回归分析中检查了血清瘦素浓度与凝血因子浓度以及血小板活化参数之间的关系。所有分析均调整了多种协变量，包括全身脂肪。
在多变量调整分析中，血清瘦素浓度每增加 1μg/L，FVIII 浓度升高 0.22IU/dL（95%CI：0.11，0.32），FIX 浓度升高 0.20IU/dL（95%CI：0.14，0.27）（FVIII 和 FIX 各增加 3.5IU/dL 和 3.2IU/dL 每 SD 瘦素）。血清瘦素浓度与 FXI、纤维蛋白原、血小板计数、平均血小板体积和血小板分布宽度在多变量调整分析中无相关性。
本研究表明，在一项观察性研究中，血清瘦素浓度与 FVIII 和 FIX 浓度升高有关，这可能具有临床意义。
