Department of Otolaryngology, The Second Hospital of Hebei Medical University, No.215 Heping West Road, Shijiazhuang 050000, Hebei, China.
Department of Otolaryngology, The Second Hospital of Hebei Medical University, No.215 Heping West Road, Shijiazhuang 050000, Hebei, China.
Oral Oncol. 2020 Apr;103:104590. doi: 10.1016/j.oraloncology.2020.104590. Epub 2020 Feb 9.
Oropharynx squamous cell cancer (OPSCC) is a type of head and neck squamous cell carcinoma. The raising OPSCC incidence is mainly attributed to human papillomavirus (HPV). HPV-related OPSCC has a relatively good prognosis, the concerns are focused on the improvement of quality-of-life (QOL). We aimed to figure out the factors which may affect the QOL of HPV-related OPSCC patients after treatment.
This study included patients with HPV-related OPSCC. The QOL of the patients were analyzed through the administration of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30)-Chinese version, the European Organization for Research and Treatment of Cancer Head and Neck Cancer Module-35 (EORTC QLQ-H&N-35)-Chinese version, and Eating Assessment Tool-10 (EAT-10). Multivariable regression analysis was employed to detect the influence of predictor variables on the QOL of patients.
A total of 294 HPV-related OPSCC patients were involved in this research. The results of EORTC QLQ-C30, EORTC QLQ-H&N-35, and EAT-10 demonstrated that the treatment decreased the QOL of HPV-related OPSCC patients. Several different factors including marital status, consumption of tobacco and alcohol, tumor sites, clinical stages, therapeutic strategies, and neck dissection were proved to have influence on QOL of HPV-related OPSCC after treatment.
Based on the analyzation of the QOL at baseline and after treatment, we demonstrated several factors which influenced the QOL of HPV-associated OPSCC patients after treatment. These results can make a great contribution to the improvement of the QOL after treatment.
口咽鳞状细胞癌（OPSCC）是头颈部鳞状细胞癌的一种。OPSCC 发病率的上升主要归因于人类乳头瘤病毒（HPV）。HPV 相关的 OPSCC 预后相对较好，关注的焦点是提高生活质量（QOL）。我们旨在研究治疗后可能影响 HPV 相关 OPSCC 患者 QOL 的因素。
本研究纳入了 HPV 相关 OPSCC 患者。通过欧洲癌症研究与治疗组织生活质量问卷核心 30 项（EORTC QLQ-C30）中文版、欧洲癌症研究与治疗组织头颈部癌症模块 35 项（EORTC QLQ-H&N-35）中文版和进食评估工具 10 项（EAT-10）对患者的 QOL 进行分析。采用多变量回归分析检测预测变量对患者 QOL 的影响。
本研究共纳入 294 例 HPV 相关 OPSCC 患者。EORTC QLQ-C30、EORTC QLQ-H&N-35 和 EAT-10 的结果表明，治疗降低了 HPV 相关 OPSCC 患者的 QOL。婚姻状况、烟酒消费、肿瘤部位、临床分期、治疗策略和颈清扫等多种不同因素均被证明对治疗后 HPV 相关 OPSCC 患者的 QOL 有影响。
通过对基线和治疗后 QOL 的分析，我们确定了一些影响 HPV 相关 OPSCC 患者治疗后 QOL 的因素。这些结果可以为改善治疗后的 QOL 做出贡献。
