Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, 410008, Hunan Province, China.
BMC Musculoskelet Disord. 2020 Feb 12;21(1):97. doi: 10.1186/s12891-020-3121-z.
Patients with chondrocalcinosis may suffer from a series of symptoms resembling acute gouty arthritis or septic arthritis, but the aetiology and pathogenesis of chondrocalcinosis have not been fully elucidated yet. This study was aimed to assess serum zinc and copper concentrations, as well as the ratio of serum copper to zinc concentrations (Cu/Zn ratio), in relation to the prevalence of knee chondrocalcinosis.
Data included in this analysis were retrieved from a large population-based cross-sectional study. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was diagnosed if definite linear cartilage calcification was detected. Serum zinc and copper concentrations were measured using the spectrophotometric flow injection methods by Roche modular P800. The relations of serum zinc and copper concentrations and Cu/Zn ratio to the prevalence of knee chondrocalcinosis were examined using generalized estimating equations, respectively.
The prevalence of knee chondrocalcinosis was 1.2% in the sample of this study (n = 12,362). In comparison with the lowest tertile, the odds ratios (ORs) of knee chondrocalcinosis adjusted by age, sex and body mass index were 0.74 (95% CI 0.50-1.09) in the second and 0.56 (95% CI 0.36-0.86) in the third tertiles of serum zinc concentrations (P for trend = 0.009), were 1.26 (95% CI 0.77-2.05) in the second and 2.01 (95% CI 1.25-3.24) in the third tertile of serum copper concentrations (P for trend = 0.003), and were 1.02 (95% CI 0.61-1.69) in the second and 2.23 (95% CI 1.38-3.59) in the third tertile of Cu/Zn ratio (P for trend < 0.001) respectively. These findings were not materially altered by adjustment for potential confounders.
The present study observed that higher serum zinc concentrations, lower serum copper concentrations or lower Cu/Zn ratio are associated with a lower prevalence of knee chondrocalcinosis in a dose-response relationship manner.
患有软骨钙质沉着症的患者可能会出现一系列类似于急性痛风性关节炎或化脓性关节炎的症状，但软骨钙质沉着症的病因和发病机制尚未完全阐明。本研究旨在评估血清锌和铜浓度以及血清铜锌比（Cu/Zn 比）与膝关节软骨钙质沉着症的患病率之间的关系。
本分析中包含的数据来自一项大型基于人群的横断面研究。从每位受试者中获得双侧膝关节前后位 X 线片。如果检测到明确的线性软骨钙化，则诊断为放射学膝关节软骨钙质沉着症。使用罗氏模块化 P800 分光光度流动注射法测量血清锌和铜浓度。使用广义估计方程分别检查血清锌和铜浓度以及 Cu/Zn 比值与膝关节软骨钙质沉着症患病率的关系。
在本研究样本中，膝关节软骨钙质沉着症的患病率为 1.2%（n=12362）。与最低三分位相比，血清锌浓度第二和第三三分位的膝关节软骨钙质沉着症调整后的优势比（OR）分别为 0.74（95%CI 0.50-1.09）和 0.56（95%CI 0.36-0.86）（P 趋势=0.009），血清铜浓度第二和第三三分位的膝关节软骨钙质沉着症的 OR 分别为 1.26（95%CI 0.77-2.05）和 2.01（95%CI 1.25-3.24）（P 趋势=0.003），Cu/Zn 比值第二和第三三分位的膝关节软骨钙质沉着症的 OR 分别为 1.02（95%CI 0.61-1.69）和 2.23（95%CI 1.38-3.59）（P 趋势<0.001）。这些发现经潜在混杂因素调整后无明显变化。
本研究观察到，血清锌浓度升高、血清铜浓度降低或 Cu/Zn 比值降低与膝关节软骨钙质沉着症的患病率呈剂量反应关系。
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