Socha Katarzyna, Karpińska Elżbieta, Kochanowicz Jan, Soroczyńska Jolanta, Jakoniuk Marta, Wilkiel Marianna, Mariak Zenon D, Borawska Maria H
Department of Bromatology, Medical University of Bialystok, Poland.
Department of Bromatology, Medical University of Bialystok, Poland.
Nutrition. 2017 Jul-Aug;39-40:76-81. doi: 10.1016/j.nut.2017.03.009. Epub 2017 Mar 23.
Dietary habits and adequate intake of antioxidants in the diet-for example, copper (Cu) and zinc (Zn)-may be an environmental factor in the occurrence of multiple sclerosis (MS). The aim of this study was to estimate the influence of dietary habits on the concentration of Cu, Zn in the serum, and the effect of Cu-to-Zn ratio on the ability status of patients with relapsing-remitting MS.
This was an observational case-control study that included 101 individuals with MS and 68 healthy individuals (controls). Food frequency questionnaires were used to collect dietary data. Serum concentrations of Cu and Zn were determined by the electrothermal and flame atomic absorption spectrometry method, respectively. The ratio of Cu to Zn was calculated and compared with the Expanded Disability Status Scale of patients.
The concentration of Zn was significantly lower in the serum of individuals with MS (0.776 ± 0.195 mg/L) than in the control group (0.992 ± 0.315 mg/L). The ratio of Cu to Zn was higher in the examined patients (1.347 ± 0.806) than in the healthy volunteers (1.012 ± 0.458). Lower ability status (P < 0.05) was revealed in patients with an abnormal ratio of Cu to Zn, particularly, in cerebellar function, pyramidal tracts, and emotional conditions. Selected dietary habits have a significant influence on Cu and Zn concentration in the serum of patients with MS.
Lower serum concentrations of Zn and higher ratio of Cu to Zn in patients with MS can suggest a relationship between MS and oxidative stress. Products that are a source of Zn should be included in the diet, which can improve the clinical condition of people with MS.
饮食习惯以及饮食中抗氧化剂（如铜（Cu）和锌（Zn））的充足摄入可能是多发性硬化症（MS）发病的一个环境因素。本研究的目的是评估饮食习惯对血清中铜、锌浓度的影响，以及铜锌比对复发缓解型MS患者功能状态的影响。
这是一项观察性病例对照研究，纳入了101例MS患者和68名健康个体（对照组）。使用食物频率问卷收集饮食数据。分别采用电热原子吸收光谱法和火焰原子吸收光谱法测定血清铜和锌的浓度。计算铜锌比，并与患者的扩展残疾状态量表进行比较。
MS患者血清中锌的浓度（0.776±0.195mg/L）显著低于对照组（0.992±0.315mg/L）。研究患者的铜锌比（1.347±0.806）高于健康志愿者（1.012±0.458）。铜锌比异常的患者，尤其是在小脑功能、锥体束和情绪状况方面，功能状态较低（P<0.05）。特定的饮食习惯对MS患者血清中的铜和锌浓度有显著影响。
MS患者血清锌浓度较低和铜锌比升高可能提示MS与氧化应激之间存在关联。饮食中应包含富含锌的食物，这有助于改善MS患者的临床状况。
