Aizawa Hiroaki, Karasaki Takahiro, Nagayama Kazuhiro, Shinozaki-Ushiku Aya, Aburatani Hiroyuki, Mano Hiroyuki, Nakajima Jun
Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Japan.
Department of Pathology, The University of Tokyo Graduate School of Medicine, Japan.
Intern Med. 2020 May 15;59(10):1299-1302. doi: 10.2169/internalmedicine.3682-19. Epub 2020 Feb 12.
An 80-year-old man with a history of cutaneous squamous cell carcinoma (SCC) was referred to our department for a solitary lung nodule. The nodule was surgically resected and diagnosed as SCC. Because the lung lesion and a previous skin lesion showed similar histological findings, the origin of the lung tumor was uncertain. Next-generation sequencing using a targeted driver oncogene panel was applied for the further examination. The lung lesion was diagnosed as primary lung SCC, as the two tumors possessed distinct somatic mutations in TP53. Recent advances in clinical sequencing have enabled us to obtain an accurate diagnosis in pathologically challenging cases.
一名有皮肤鳞状细胞癌（SCC）病史的80岁男性因孤立性肺结节被转诊至我科。该结节经手术切除，诊断为SCC。由于肺部病变和先前的皮肤病变显示出相似的组织学特征，肺肿瘤的起源尚不确定。应用靶向驱动癌基因panel的二代测序进行进一步检查。由于两个肿瘤在TP53基因中存在不同的体细胞突变，肺部病变被诊断为原发性肺SCC。临床测序的最新进展使我们能够在病理诊断具有挑战性的病例中获得准确诊断。
