Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
J Clin Endocrinol Metab. 2020 Apr 1;105(4):1119-25. doi: 10.1210/clinem/dgaa072.
Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As GLP-1 receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary to determine the effects of GLP-1 on the reproductive system in humans.
To investigate the effects of GLP-1 administration on the reproductive axis in humans.
Single-blind, randomized, placebo-controlled crossover study.
Clinical Research Facility, Imperial College Healthcare NHS Trust.
Eighteen healthy men (mean age 24.7 ± 0.1years, mean BMI 22.1 ± 0.4kg/m2).
Eight-hour intravenous infusion of 0.8 pmol/kg/min GLP-1 or rate-matched vehicle infusion.
Number of luteinizing hormone (LH) pulses, LH, follicle-stimulating hormone (FSH), and testosterone levels.
The number of LH pulses (number of LH pulses/500 min: vehicle 4.2 ± 0.4, GLP-1 4.5 ± 0.3, P = 0.46), LH area under the curve (AUC) (vehicle 1518 ± 88min.IU/L, GLP-1 1524 ± 101min.IU/L, P = 0.95), follicle-stimulating hormone AUC (vehicle 1210 ± 112 min IU/L, GLP-1 1216 ± 112 min IU/L, P = 0.86), and testosterone AUC (vehicle 10893 ± 615 min nmol/L, GLP-1 11088 ± 792 min nmol/L, P = 0.77) did not significantly differ during vehicle and GLP-1 administration. Glucagon-like peptide-1 significantly reduced food intake (vehicle 15.7 ± 1.3 kcal/kg, GLP-1 13.4 ± 1.3 kcal/kg, P = 0.01).
In contrast to the animal literature, our data demonstrate that acute GLP-1 administration does not affect reproductive hormone secretion in healthy men.
胰高血糖素样肽-1（GLP-1）能有效抑制食欲并增强葡萄糖刺激的胰岛素分泌。最近的动物数据表明，GLP-1 可能还会影响生殖。由于 GLP-1 受体激动剂目前广泛用于治疗肥胖症/2 型糖尿病的临床实践中，因此有必要确定 GLP-1 对人体生殖系统的影响。
研究 GLP-1 给药对人体生殖轴的影响。
单盲、随机、安慰剂对照交叉研究。
帝国理工学院医疗保健 NHS 信托基金临床研究设施。
18 名健康男性（平均年龄 24.7 ± 0.1 岁，平均 BMI 22.1 ± 0.4kg/m2）。
8 小时静脉输注 0.8pmol/kg/min GLP-1 或速率匹配的载体输注。
黄体生成素（LH）脉冲数、LH、卵泡刺激素（FSH）和睾酮水平。
LH 脉冲数（LH 脉冲数/500min：载体 4.2 ± 0.4，GLP-1 4.5 ± 0.3，P = 0.46）、LH 曲线下面积（AUC）（载体 1518 ± 88min.IU/L，GLP-1 1524 ± 101min.IU/L，P = 0.95）、卵泡刺激素 AUC（载体 1210 ± 112minIU/L，GLP-1 1216 ± 112minIU/L，P = 0.86）和睾酮 AUC（载体 10893 ± 615minnmol/L，GLP-1 11088 ± 792minnmol/L，P = 0.77）在载体和 GLP-1 给药期间无显著差异。GLP-1 显著减少了食物摄入量（载体 15.7 ± 1.3kcal/kg，GLP-1 13.4 ± 1.3kcal/kg，P = 0.01）。
与动物文献相反，我们的数据表明，急性 GLP-1 给药不会影响健康男性的生殖激素分泌。
