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The effects of kisspeptin on food intake in women with overweight or obesity.

作者信息

Izzi-Engbeaya Chioma, Choudhury Muhammad M, Patel Bijal, Muzi Beatrice, Qayuum Ambreen, Mills Edouard G, Ahsan Maheen, Phylactou Maria, Clarke Sophie A, Aslett Laura, Comninos Alexander N, Abbara Ali, Tan Tricia M, Dhillo Waljit S

机构信息

Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.

Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Diabetes Obes Metab. 2023 Aug;25(8):2393-2397. doi: 10.1111/dom.15086. Epub 2023 Apr 25.

DOI:10.1111/dom.15086
PMID:37039248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10946989/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3f/10946989/4f001c08da15/DOM-25-2393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3f/10946989/17ad42b61dab/DOM-25-2393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3f/10946989/4f001c08da15/DOM-25-2393-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3f/10946989/17ad42b61dab/DOM-25-2393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b3f/10946989/4f001c08da15/DOM-25-2393-g001.jpg

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本文引用的文献

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Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model.靶向肝脏 kisspeptin 受体可改善小鼠非酒精性脂肪性肝病。
J Clin Invest. 2022 May 16;132(10). doi: 10.1172/JCI145889.
2
Estradiol and appetite: To eat or not to eat.雌二醇与食欲：吃还是不吃。
Mol Metab. 2020 Dec;42:101061. doi: 10.1016/j.molmet.2020.101061. Epub 2020 Aug 6.
3
Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men.胰高血糖素样肽-1 对健康男性生殖轴的影响。
J Clin Endocrinol Metab. 2020 Apr 1;105(4):1119-25. doi: 10.1210/clinem/dgaa072.
4
Intraperitoneal Treatment of Kisspeptin Suppresses Appetite and Energy Expenditure and Alters Gastrointestinal Hormones in Mice.腹腔内给予 kisspeptin 可抑制食欲和能量消耗，并改变小鼠的胃肠激素。
Dig Dis Sci. 2020 Aug;65(8):2254-2263. doi: 10.1007/s10620-019-05950-7. Epub 2019 Nov 15.
5
Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis.促性腺激素依赖性与非依赖性 kisspeptin 信号在体重控制和代谢稳态中的作用。
Metabolism. 2019 Sep;98:84-94. doi: 10.1016/j.metabol.2019.06.007. Epub 2019 Jun 19.
6
Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats.中枢给予 kisspeptin 通过 nesfatin-1 和催产素抑制雄性大鼠摄食。
Peptides. 2019 Feb;112:114-124. doi: 10.1016/j.peptides.2018.12.003. Epub 2018 Dec 16.
7
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans. kisspeptin 对人类胰岛β细胞功能、血清代谢物和食欲的影响。
Diabetes Obes Metab. 2018 Dec;20(12):2800-2810. doi: 10.1111/dom.13460. Epub 2018 Aug 16.
8
Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity.促性腺激素释放激素神经元激活肽信号受损会降低新陈代谢，并导致葡萄糖耐受不良和肥胖。
J Clin Invest. 2014 Jul;124(7):3075-9. doi: 10.1172/JCI71075. Epub 2014 Jun 17.
9
Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.中枢注射 kisspeptin 通过增加小鼠的进食间隔来减少食物摄入量。
Neuroreport. 2011 Mar 30;22(5):253-7. doi: 10.1097/WNR.0b013e32834558df.
10
Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.kisspeptin 通过间接的突触机制直接兴奋厌食性 proopiomelanocortin 神经元，抑制食欲性神经肽 Y 细胞。
J Neurosci. 2010 Jul 28;30(30):10205-19. doi: 10.1523/JNEUROSCI.2098-10.2010.