Department of Radiation Oncology, Penn State Cancer Institute.
Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Toxicol Sci. 2020 May 1;175(1):19-23. doi: 10.1093/toxsci/kfaa021.
Pancreatic cancer is a highly fatal malignancy for which surgery is currently considered to be the only curative treatment. However, less than a quarter of patients have disease amenable to definitive surgical resection. Local treatment with radiation therapy is a promising alternative to surgery for those patients with unresectable disease. However, conventional radiation techniques with computed tomography (CT)-guided therapy have yielded disappointing results due to the inability to deliver ablative doses of ionizing radiation, while sparing the radiosensitive adjacent organs at risk. Magnetic resonance-guided radiotherapy (MRgRT) has emerged as an alternative to CT-guided radiation treatment which allows for the delivery of higher doses of radiation with low toxicity to surrounding structures. Further study into the use of MRgRT and dose escalation for locally advanced unresectable pancreatic cancer is needed.
胰腺癌是一种高度致命的恶性肿瘤，目前手术被认为是唯一的治愈性治疗方法。然而，只有不到四分之一的患者的疾病适合进行确定性手术切除。对于那些无法手术切除的患者，局部放射治疗是一种有前途的替代手术方法。然而，由于无法提供消融剂量的电离辐射，同时保护相邻的辐射敏感器官，传统的基于计算机断层扫描（CT）引导的放射治疗技术的效果并不理想。磁共振引导放射治疗（MRgRT）作为 CT 引导放射治疗的替代方法已经出现，它可以在不增加周围结构毒性的情况下，提供更高剂量的辐射。需要进一步研究 MRgRT 的使用和局部晚期不可切除胰腺癌的剂量递增。
