Asari S, Nishimoto A, Murakami M
Department of Neurological Surgery, Okayama University Medical School.
No Shinkei Geka. 1988 Aug;16(9):1079-82.
Anterior communicating artery aneurysm was shown in a 48-year-old man who had suffered from subarachnoid hemorrhage (SAH) by cerebral angiography. Right pterional approach was performed on the 40th day after SAH. Premature ruptured occurred during aneurysmal manipulation and temporary clip (Scoville clip) was placed at the middle of the right A1 segment for fifteen minutes. the anterior communicating artery aneurysm was successfully clipped and postoperative course was uneventful. But, four days after the operation, the patient fell into coma following generalized tonic convulsion. Lumbar puncture showed fresh SAH. Consciousness recovered gradually to a lethargic state. A newly formed berry aneurysm was revealed on the righ A1 segment at the site of the temporary clip application by cerebral angiography performed on the seventh day after aneurysmal surgery. Second attack occurred on the 12th postoperative day and the patient died on the 16th day after the operation. Postmortem findings disclosed massive subarachnoid and intraventricular hemorrhage from the ruptured aneurysm at the right A1 segment. Microscopic examination of the aneurysm and the right A1 segment. microscopic examination of the aneurysm and the right A1 segment showed the extensive destruction of the artery and massive proliferation of aspergillus in the arterial wall which was prominent of its outer layer. The mechanism of the formation of the new aneurysm in this case was considered as follows: the arterial wall was primarily damaged by the temporary clip and was weakened rapidly by the invasion of aspergillus, probably producing thrombosis of the vast vasorum, hemorrhage, and necrosis in it.
一名48岁男性因蛛网膜下腔出血(SAH)行脑血管造影显示前交通动脉瘤。SAH后第40天采用右侧翼点入路。动脉瘤操作过程中发生过早破裂,临时夹(斯科维尔夹)置于右侧A1段中部15分钟。前交通动脉瘤成功夹闭,术后过程顺利。但术后4天,患者在全身强直性惊厥后陷入昏迷。腰椎穿刺显示新鲜SAH。意识逐渐恢复至嗜睡状态。动脉瘤手术后第7天进行脑血管造影显示,在临时夹应用部位的右侧A1段发现一个新形成的浆果状动脉瘤。术后第12天发生第二次发作,患者于术后第16天死亡。尸检结果显示,右侧A1段破裂动脉瘤导致大量蛛网膜下腔和脑室内出血。对动脉瘤和右侧A1段进行显微镜检查。显微镜检查显示动脉广泛破坏,动脉壁外层曲霉菌大量增殖。该病例中新动脉瘤形成的机制如下:动脉壁首先受到临时夹的损伤,随后因曲霉菌入侵而迅速减弱,可能导致大量血管滋养管血栓形成、出血和坏死。