游离葡萄糖监测系统所致接触性皮炎的患病率及预防：单中心经验。
Prevalence and Prevention of Contact Dermatitis Caused by FreeStyle Libre: A Monocentric Experience.
机构信息
Department of Dermatology, Antwerp University Hospital, Antwerp, Belgium.
University of Antwerp, Antwerp, Belgium.
出版信息
Diabetes Care. 2020 Apr;43(4):918-920. doi: 10.2337/dc19-1354. Epub 2020 Feb 13.
OBJECTIVE
Cutaneous adverse events (CAE) from FreeStyle Libre include allergic contact dermatitis (ACD) caused by the allergen isobornyl acrylate (IBOA). We aim to report CAE from this glucose sensor, ACD to IBOA in particular, and the outcome of using barrier films as a prevention.
RESEARCH DESIGN AND METHODS
A monocentric, retrospective review of medical files from adult and pediatric patients with diabetes using Freestyle Libre, in the period between December 2016 and April 2019, was performed with a focus on CAE.
RESULTS
Fifty-seven of 1,036 patients with diabetes (5.5%) were referred to our dermatology department because of CAE from FreeStyle Libre. Thirty-nine of 1,036 (3.8%) had ACD due to IBOA. Only two patients, of whom one sensitized to IBOA, had a benefit from using barrier films.
CONCLUSIONS
CAE occurred in 5.5% of FreeStyle Libre users, and 3.8% suffered from ACD due to IBOA. Barrier films had limited value in the prevention.
目的
FreeStyle Libre 引起的皮肤不良反应（CAE）包括由变应原异冰片丙烯酸酯（IBOA）引起的过敏性接触性皮炎（ACD）。我们旨在报告来自这种葡萄糖传感器的 CAE，特别是 ACD，以及使用屏障膜作为预防措施的结果。
研究设计和方法
对 2016 年 12 月至 2019 年 4 月期间使用 Freestyle Libre 的成年和儿科糖尿病患者的医疗档案进行了单中心、回顾性分析，重点关注 CAE。
结果
在 1036 名糖尿病患者中，有 57 名（5.5%）因 Freestyle Libre 的 CAE 而被转至皮肤科。在 1036 名患者中有 39 名（3.8%）因 IBOA 而患有 ACD。只有两名患者（其中一名对 IBOA 过敏）使用屏障膜有获益。
结论
FreeStyle Libre 的使用者中有 5.5%出现 CAE，3.8%因 IBOA 而患有 ACD。屏障膜在预防方面的作用有限。
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