Measurement of beta-adrenoceptor antagonists in biological fluids using a radioreceptor assay.
作者信息
Nahorski S R, Batta M I, Barnett D B
出版信息
Eur J Pharmacol. 1978 Dec 1;52(3-4):393-6. doi: 10.1016/0014-2999(78)90296-0.
PMID:32055
Abstract
A new assay for plasma levels of beta-adrenoceptor antagonists is described. The assay depends upon the ability of the drug to compete with a labelled beta-adrenoceptor antagonist (-)-[3H]dihydroalprenolol for beta-adrenoceptor binding sites on lung membranes. The assay is simple to perform, very sensitive and does not require prior extraction of plasma. The assay can also detect bioactive metabolites of these agents and is clearly not limited to a single beta-adrenoceptor antagonist.
摘要
相似文献
1
Measurement of beta-adrenoceptor antagonists in biological fluids using a radioreceptor assay.
Eur J Pharmacol. 1978 Dec 1;52(3-4):393-6. doi: 10.1016/0014-2999(78)90296-0.
2
Evaluation of a radioreceptor assay for beta-adrenoceptor antagonists in plasma.
Eur J Clin Pharmacol. 1980 May;17(5):349-54. doi: 10.1007/BF00558447.
3
Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma.用于检测天然人血浆中β-肾上腺素能受体拮抗剂及其活性代谢物的简单可靠的放射受体分析法。
Eur J Clin Pharmacol. 1984;27(5):545-53. doi: 10.1007/BF00556890.
4
Radioreceptor assay for serum levels of cetamolol, a new beta-adrenoceptor antagonist.
Clin Biochem. 1984 Jun;17(3):162-5. doi: 10.1016/s0009-9120(84)80150-2.
5
6
Phenylethanolaminotetralines compete with [3H]dihydroalprenolol binding to rat colon membranes without evidencing atypical beta-adrenergic sites.苯乙醇胺四氢萘类化合物能与[3H]二氢烯丙洛尔竞争结合大鼠结肠膜，且未显示出非典型β-肾上腺素能位点。
Biochem Pharmacol. 1992 Aug 18;44(4):665-72. doi: 10.1016/0006-2952(92)90401-4.
7
Development of a radioreceptor assay for beta-adrenoceptor antagonists in plasma [proceedings].血浆中β-肾上腺素能受体拮抗剂的放射受体分析法的开发[会议论文集]
Br J Pharmacol. 1978 Nov;64(3):449P.
8
[3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification.[3H]-RS-15385-197，一种对α2肾上腺素能受体具有选择性和高亲和力的放射性配体：对受体分类的意义
Br J Pharmacol. 1992 Aug;106(4):1011-8. doi: 10.1111/j.1476-5381.1992.tb14449.x.
9
Vanidilol: a vanilloid-type vasorelaxant and ocular hypotensive beta-adrenoceptor blocker with partial beta-2-agonist activity.伐尼地洛：一种具有香草酸类血管舒张作用和降眼压作用的β肾上腺素受体阻滞剂，具有部分β2激动剂活性。
Pharmacology. 1997 Apr;54(4):211-24. doi: 10.1159/000139489.
10
A sensitive radioligand binding assay for timolol in plasma.
J Pharm Sci. 1991 Mar;80(3):296-9. doi: 10.1002/jps.2600800322.
引用本文的文献
1
Radioreceptor assay for labetalol.拉贝洛尔的放射受体测定法。
Br J Clin Pharmacol. 1981 Aug;12(2):258-60. doi: 10.1111/j.1365-2125.1981.tb01214.x.
2
Proceeding of the British Pharmacological Society, Clinical Pharmacology Section, 16-18th December, 1980, University of London. Abstracts.英国药理学会临床药理学分会会议记录，1980年12月16日至18日，伦敦大学。摘要
Br J Clin Pharmacol. 1981 Apr;11(4):409P-439P. doi: 10.1111/j.1365-2125.1981.tb01148.x.
3
Radioligand binding studies of adrenergic receptors and their clinical relevance.肾上腺素能受体的放射性配体结合研究及其临床意义。
Br Med J (Clin Res Ed). 1981 Apr 11;282(6271):1207-10. doi: 10.1136/bmj.282.6271.1207.
4
Evaluation of a radioreceptor assay for beta-adrenoceptor antagonists in plasma.
Eur J Clin Pharmacol. 1980 May;17(5):349-54. doi: 10.1007/BF00558447.
5
Analysis of the activity and distribution of beta-adrenoceptor antagonists in the rat using an ex vivo receptor binding assay [proceedings].
Br J Pharmacol. 1979 Nov;67(3):415P.
Zotero 插件