通过铑催化的外消旋烯丙基氯的烯丙基芳基化实现高度对映选择性的日向交叉偶联反应。
Highly Enantioselective Hiyama Cross-Coupling via Rh-Catalyzed Allylic Arylation of Racemic Allyl Chlorides.
作者信息
González Jesús, Schäfer Philipp, Fletcher Stephen P
机构信息
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom.
出版信息
Organometallics. 2019 Oct 28;38(20):3991-3995. doi: 10.1021/acs.organomet.9b00197. Epub 2019 May 10.
Abstract
Highly enantioselective Hiyama cross-coupling reactions have been achieved through rhodium(I)-catalyzed dynamic kinetic asymmetric transformations between aryl siloxanes and cyclic racemic allyl halides. This process affords valuable enantiomerically enriched aryl-substituted cyclic allyl products and is compatible with heterocyclic allyl chloride electrophiles.
摘要
通过铑（I）催化芳基硅氧烷与环状外消旋烯丙基卤化物之间的动态动力学不对称转化，实现了高度对映选择性的日山交叉偶联反应。该过程提供了有价值的对映体富集的芳基取代环状烯丙基产物，并且与杂环烯丙基氯亲电试剂兼容。
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