Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Department of General Internal Medicine, Centre Hospitalier Universitaire de Québec, Hôpital St-François d'Assise, Université Laval, Québec, QC, Canada.
J Thromb Thrombolysis. 2020 Oct;50(3):674-677. doi: 10.1007/s11239-020-02062-2.
Persisting heparin-induced thrombocytopenia (HIT) is characterized by ongoing thrombocytopenia more than 7 days after stopping heparin. It is part of cases referred to as autoimmune HIT (aHIT). In contrast to typical HIT cases, aHIT involves heparin-independent platelet activation mechanism highlighted by a strongly positive functional assay done without heparin. We report the first case of persisting HIT after an elective abdominal aortic aneurysm repair presenting with arterial and venous thrombosis, and describe the potential role of intravenous immunoglobulin in such patients.
持续性肝素诱导的血小板减少症 (HIT) 的特征是在停用肝素后 7 天以上持续存在血小板减少症。它是被称为自身免疫性 HIT (aHIT) 的病例的一部分。与典型的 HIT 病例不同，aHIT 涉及肝素非依赖性血小板激活机制，其特点是在没有肝素的情况下进行的功能检测呈强阳性。我们报告了首例在选择性腹主动脉瘤修复后出现动脉和静脉血栓形成的持续性 HIT 病例，并描述了静脉注射免疫球蛋白在这类患者中的潜在作用。
