Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan
Department of Pharmacy, University of Lahore, Gujrat Campus, Gujrat, Pakistan
Curr Pharm Des. 2020;26(22):2574-2582. doi: 10.2174/1381612826666200214161139.
Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors that are involved in the disease. The present review discusses our current knowledge of the major cellular and molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studies have evaluated the antiatherosclerotic activity of phytoconstituents to provide preliminary evidence of efficacy, but only a few studies have delineated the underlying molecular mechanisms. Plant-derived phytotherapeutics primarily targets abnormal levels of lipoproteins, endothelial dysfunction, smooth muscle cell migration, foam cell development, and atheromatous plaque formation. Nonetheless, the principal mechanisms that are responsible for their therapeutic actions remain unclear. Further pharmacological studies are needed to elucidate the underlying molecular mechanisms of the antiatherosclerotic response to these phytoconstituents.
动脉粥样硬化是一种心血管疾病，涉及通过发展成脂肪条纹和斑块的血管。植物化合物可以通过影响参与疾病的各种因素来帮助治疗或预防动脉粥样硬化。本综述讨论了我们目前对植物疗法治疗动脉粥样硬化的主要细胞和分子机制的认识。许多研究已经评估了植物成分的抗动脉粥样硬化活性，为疗效提供了初步证据，但只有少数研究描述了潜在的分子机制。植物来源的植物疗法主要针对脂蛋白异常水平、内皮功能障碍、平滑肌细胞迁移、泡沫细胞形成和粥样斑块形成。尽管如此，其治疗作用的主要机制尚不清楚。需要进一步的药理学研究来阐明这些植物成分抗动脉粥样硬化反应的潜在分子机制。
