Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Department of Cell Biology, School of Life Sciences, Central South University, Changsha, 410013, China.
Virology. 2020 Apr;543:34-42. doi: 10.1016/j.virol.2020.01.015. Epub 2020 Feb 2.
Zika Virus (ZIKV) is a Flavivirus transmitted primarily via the bite of infected Aedes aegypti mosquitoes. Globally, 87 countries and territories have recorded autochthonous mosquito-borne transmission of ZIKV as at July 2019 and distributed across four of the six WHO Regions. Outbreaks of ZIKV infection peaked in 2016 and declined substantially throughout 2017 and 2018 in the Americas region. There is the likely risk for ZIKV to spread to more countries. There is also the potential for the re-emergence of ZIKV in all places with prior reports of the virus transmission. The current status of ZIKV transmission and spread is, however, a global health threat, and from the aforementioned, has the potential to re-emerge as an epidemic. This review summarizes the past and present spread of ZIKV outbreak-2007-2019, the genome, transmission cycle, clinical manifestations, vaccine and antiviral drug advancement.
Zika 病毒（ZIKV）是一种黄病毒，主要通过受感染的埃及伊蚊叮咬传播。截至 2019 年 7 月，全球有 87 个国家和地区记录了本地蚊媒传播的 ZIKV，分布在世界卫生组织六个区域中的四个区域。2016 年，ZIKV 感染疫情达到高峰，2017 年和 2018 年，美洲地区的疫情大幅下降。ZIKV 有可能传播到更多的国家。在先前有病毒传播报告的所有地方，也有可能再次出现 ZIKV。然而，目前 ZIKV 的传播和扩散状况是一个全球卫生威胁，从上述情况来看，它有可能再次成为一种流行病。本综述总结了过去和现在的 ZIKV 疫情爆发情况（2007-2019 年）、基因组、传播周期、临床表现、疫苗和抗病毒药物的进展。
