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中毒性表皮坏死松解症后双侧全眼球炎:病例报告。

Bilateral panophthalmitis following toxic epidermal necrolysis: A case report.

机构信息

Department of Ophthalmology, Government Medical College, Miraj, Maharashtra, India.

出版信息

Indian J Ophthalmol. 2020 Mar;68(3):538-540. doi: 10.4103/ijo.IJO_1208_19.

DOI:10.4103/ijo.IJO_1208_19
PMID:32057029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7043163/
Abstract

A 70 year old man presented with systemic signs of toxic epidermal necrolysis (TEN) following consumption of diclofenac tablets for a prodromal illness a week back. Ophthalmic evaluation showed no perception of light in both eyes along with lid edema, total corneal sloughing, and pus-filled anterior chamber. An amniotic membrane transplant was planned but within a few hours, both eyes developed panophthalmitis with restricted extraocular movements and mild proptosis and had to be eviscerated. This is perhaps the first case showing such devastating sequelae of TEN.

摘要

一位 70 岁男性,在一周前因前驱疾病服用双氯芬酸片后出现全身中毒性表皮坏死松解症(TEN)的症状。眼部评估显示双眼无光感,伴有眼睑水肿、全角膜脱落和充满脓液的前房。计划进行羊膜移植,但在数小时内,双眼均发生全眼炎,伴有眼球运动受限、轻度眼球突出,不得不进行眼内容剜除。这可能是首例显示 TEN 如此严重后果的病例。

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本文引用的文献

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A Review of the Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的治疗综述
Adv Emerg Nurs J. 2019 Jan/Mar;41(1):56-64. doi: 10.1097/TME.0000000000000225.
2
Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.史蒂文斯-约翰逊综合征伴有严重眼部并发症的详细调查结果。
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES183-DES191. doi: 10.1167/iovs.17-23537.
3
Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital.
史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症患儿的临床特征及治疗结果:在一家三级转诊医院进行的20年研究
Dermatol Res Pract. 2018 May 7;2018:3061084. doi: 10.1155/2018/3061084. eCollection 2018.
4
Stevens-Johnson syndrome: The role of an ophthalmologist.史蒂文斯-约翰逊综合征:眼科医生的作用
Surv Ophthalmol. 2016 Jul-Aug;61(4):369-99. doi: 10.1016/j.survophthal.2016.01.004. Epub 2016 Jan 30.
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Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease.史蒂文斯 - 约翰逊综合征/中毒性表皮坏死松解症——全面综述与治疗指南。I. 全身性疾病
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6
Amniotic membrane transplantation in acute toxic epidermal necrolysis: histopathologic changes and ocular surface features after 1-year follow-up.急性中毒性表皮坏死松解症的羊膜移植:1年随访后的组织病理学变化及眼表特征
Eur J Ophthalmol. 2014 Sep-Oct;24(5):667-75. doi: 10.5301/ejo.5000434.
7
Ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis.中毒性表皮坏死松解症随访过程中的眼部特征和组织病理学变化。
Ophthalmology. 2011 Feb;118(2):265-71. doi: 10.1016/j.ophtha.2010.06.035. Epub 2010 Sep 29.
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J Cataract Refract Surg. 2007 Sep;33(9):1644-6. doi: 10.1016/j.jcrs.2007.04.041.
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