Division of Pulmonology, Department of Pediatrics, Faculty of Medicine, Ege University, Bornova, Turkey.
Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ege University, Bornova, Turkey.
Pediatr Pulmonol. 2020 May;55(5):1147-1153. doi: 10.1002/ppul.24688. Epub 2020 Feb 14.
With the increase in life expectancy, cardiovascular complications of cystic fibrosis (CF) have come to the forefront. Increased arterial stiffness is a marker of increased cardiovascular risk. The aim of this study was to compare both pulse wave velocity (PWV) and augmentation index (Aix) measurements in children with CF and to compare them with healthy controls. We hypothesized that children with CF had increased arterial stiffness, although traditional risk factors for CVD were not observed. Forty-four patients and age and sex-matched 30 healthy controls were included in the study. Hemodynamic measurements were compared in both groups, together with traditional risk factors. Peripheral blood pressure parameters of CF and control groups were similar (P > .05). Bodyweight and BMI were significantly lower in the CF group (P < .001). Serum cholesterol, HDL, and LDL levels were significantly lower in the CF group, whereas fasting blood glucose and triglyceride levels were significantly higher than the control group (P < .05). Mean ± SD Aix was significantly higher in the CF group (33.22 ± 13.87%) compared with the control group (24.93 ± 10.58%), respectively (P < .05), while PWV was similar. No significant correlation between PWV and Aix and fasting blood glucose and lipid profile in both groups (P > .05). Children with CF have been shown to have increased arterial stiffness compared to healthy children. Although there are not many traditional risk factors, increased arterial stiffness have been demonstrated in children with CF. The effects of this process starting from childhood on the development of CVD in adulthood are not known. Therefore, further studies are needed.
随着预期寿命的延长，囊性纤维化 (CF) 的心血管并发症已成为首要问题。动脉僵硬度增加是心血管风险增加的标志。本研究的目的是比较 CF 患儿和健康对照组的脉搏波速度 (PWV) 和增强指数 (Aix) 测量值，并将其进行比较。我们假设 CF 患儿的动脉僵硬度增加，尽管没有观察到 CVD 的传统危险因素。本研究纳入了 44 例 CF 患儿和年龄、性别匹配的 30 例健康对照组。比较了两组的血流动力学测量值以及传统危险因素。CF 组和对照组的外周血压参数相似（P>.05）。CF 组的体重和 BMI 明显较低（P<.001）。CF 组的血清胆固醇、HDL 和 LDL 水平明显较低，而空腹血糖和甘油三酯水平明显高于对照组（P<.05）。与对照组（24.93±10.58%）相比，CF 组的平均 Aix（33.22±13.87%）明显更高（P<.05），而 PWV 则相似。两组的 PWV 和 Aix 与空腹血糖和血脂谱之间均无显著相关性（P>.05）。与健康儿童相比，CF 患儿的动脉僵硬度增加。尽管传统危险因素不多，但 CF 患儿的动脉僵硬度增加。这种从儿童期开始对成年期 CVD 发展的影响尚不清楚。因此，需要进一步的研究。
