出生时接种卡介苗与婴儿期白细胞计数的差异。一项随机临床试验。

Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial.

机构信息

Department of Pediatrics, Copenhagen University Hospital, Hvidovre, Denmark.

出版信息

Vaccine. 2020 Mar 4;38(11):2449-2455. doi: 10.1016/j.vaccine.2020.02.006. Epub 2020 Feb 10.

DOI:10.1016/j.vaccine.2020.02.006

PMID:32057570

Abstract

BACKGROUND

The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants.

METHOD

The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (10 cells/L)) measured in peripheral blood.

RESULTS

Overall, we found no effect of BCG on differential WBC counts at any time point.

CONCLUSION

BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.

摘要

背景

卡介苗（BCG）疫苗可预防结核病（TB），除了对 TB 的保护作用外，还可能具有有益的非特异性效应（NSEs）。这可能与先天免疫系统的改变有关。我们研究了出生时接种 BCG 对丹麦健康婴儿白细胞（WBC）分类计数的影响。

方法

丹麦卡介苗研究将新生儿随机分为出生时接种 BCG（丹麦株 1331，国家血清研究所）或不干预。亚组婴儿在随机分组后 4 天（n=161）和 3 个月（n=152）和 13 个月（n=300）采集血液样本。我们评估了 BCG 对外周血中白细胞分类计数（总白细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、中性粒细胞和嗜碱性粒细胞（10 个细胞/L））的影响。