胰岛和胰腺导管腺癌——从“基础到临床”转化研究的机会。

Islets and pancreatic ductal adenocarcinoma - An opportunity for translational research from the 'Bench to the Bedside'.

机构信息

Division of Surgery and Perioperative Medicine, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, Australia; College of Medicine and Public Health, Flinders University, South Australia, Australia.

出版信息

Pancreatology. 2020 Apr;20(3):385-390. doi: 10.1016/j.pan.2020.02.001. Epub 2020 Feb 5.

DOI:10.1016/j.pan.2020.02.001

PMID:32057682

Abstract

The islet-acinar axis is of prime importance to the optimal functioning of the human pancreas. Not only is this inter-relationship important for normal physiological processes, it is also relevant in diseased states, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Early experiments, nearly 4 decades ago, explored the role of islets in the development and progression of PDAC. These led to further studies that provided compelling evidence to support the role of islets and their hormones in PDAC. This association presents oncologists with therapeutic options not only for managing, but potentially preventing PDAC, a cancer that is well known for its poor patient outcomes. This review will discuss the accumulated evidence regarding the role of islets and their hormones in PDAC and highlight areas for future research.

摘要

胰岛-腺泡轴对于人类胰腺的最佳功能至关重要。这种相互关系不仅对正常的生理过程很重要，而且在疾病状态下也很重要，包括慢性胰腺炎和胰腺导管腺癌（PDAC）。近 40 年前的早期实验探讨了胰岛在 PDAC 发展和进展中的作用。这些实验进一步的研究提供了令人信服的证据，支持了胰岛及其激素在 PDAC 中的作用。这种关联为肿瘤学家提供了治疗选择，不仅可以用于治疗，而且有可能预防 PDAC，这种癌症的患者预后很差是众所周知的。本文将讨论关于胰岛及其激素在 PDAC 中的作用的累积证据，并强调未来研究的领域。