临床特征对孕妇 DHA 及其他多不饱和脂肪酸状况的影响：系统评价。
Influence of clinical characteristics on maternal DHA and other polyunsaturated fatty acid status in pregnancy: A systematic review.
机构信息
School of Pharmacy and Medical Sciences, University of South Australia, North Terrace & Frome Rd, Adelaide, SA, 5000, Australia.
South Australian Health and Medical Research Institute SAHMRI Women and Kids, Level 7, 72 King William Rd, North Adelaide, SA, 5006, Australia.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2020 Mar;154:102063. doi: 10.1016/j.plefa.2020.102063. Epub 2020 Jan 30.
INTRODUCTION
Omega-3 DHA is important for the prevention of preterm birth, however there is limited knowledge of the determinants of omega-3 status during pregnancy. The primary objective of this systematic review was to synthesise data from existing studies assessing relationships between clinical factors and maternal DHA status.
MATERIALS AND METHODS
The Medline, Embase, Amed, and CINAHL databases were searched for studies reporting measures of maternal omega-3 status and one or more clinical characteristics.
RESULTS
Eighteen studies were included in the final analyses. Factors associated with a higher BMI (overweight, higher gestational weight gain, gestational diabetes), or lower parity were each associated with higher omega-3 status in the majority of studies, with mixed findings for other comparisons.
DISCUSSION
Inconsistent findings between studies make it difficult to draw clear conclusions about the relationship between clinical factors and maternal omega-3 DHA status. However, maternal overweight and associated metabolic conditions may increase lipid metabolism.
简介
ω-3 DHA 对预防早产很重要，但目前对妊娠期间ω-3 状态的决定因素知之甚少。本系统评价的主要目的是综合现有研究的数据，评估临床因素与产妇 DHA 状态之间的关系。
材料和方法
检索 Medline、Embase、Amed 和 CINAHL 数据库，以获取报告母体 ω-3 状态和一个或多个临床特征的研究。
结果
最终分析纳入了 18 项研究。在大多数研究中，与较高 BMI（超重、较高的妊娠体重增加、妊娠糖尿病）或较低产次相关的因素与较高的 ω-3 状态相关，而其他比较的结果则不一致。
讨论
研究之间的不一致结果使得很难就临床因素与产妇 ω-3 DHA 状态之间的关系得出明确的结论。然而，产妇超重和相关的代谢状况可能会增加脂质代谢。
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