Poluga Jasmina, Barac Aleksandra, Katanic Natasa, Rubino Salvatore, Milosevic Branko, Urosevic Aleksandar, Mitrovic Nikola, Kelic Ivana, Micic Jelena, Stevanovic Goran
Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
J Infect Dev Ctries. 2019 Jun 30;13(6):510-515. doi: 10.3855/jidc.11516.
In the Europe, the number of tick-borne encephalitis (TBE) has been increased in the last decade, and the number of endemic areas has been also increased and is still growing. In the present case series, we present clinical and socio-epidemiological data of patients with TBE hospitalized in the period of TBE virus epidemic in Serbia.
A case series was conducted in Serbia in 2017. Patients with confirmed TBE were included in the study. Biochemical and serological analysis of blood and CSF, as well as radiological imaging (CT and MRI) were done.
In total, 10 patients with TBE were included in the study. M:F ratio was 1.5:1, while average age was 45.1 years. Half of the patients had severe clinical picture. Endocranial CT scan and MRI did not reveal any abnormality, except in the patient with the most severe CNS infection (meningoencephalomyelitis). Mean value of sedimentation and CRP was slightly elevated (29.6 mm/1hours and 20.1 mg/L, respectively) in 80% of the patients, although elevation was almost negligible. The average number of leucocytes in the cerebrospinal fluid (CSF) was 171×106/L, the mean value of the CSF protein was 1.1g/L. There were no fatal outcomes.
Since other CNS infections have similar clinical picture and CSF finding as TBE, serological analysis for TBE should be included in routine diagnostic practice.
在欧洲，过去十年中蜱传脑炎（TBE）的病例数有所增加，流行地区数量也在增加且仍在增长。在本病例系列中，我们呈现了塞尔维亚TBE病毒流行期间住院的TBE患者的临床和社会流行病学数据。
2017年在塞尔维亚开展了一项病例系列研究。确诊为TBE的患者被纳入研究。对血液和脑脊液进行了生化及血清学分析，并进行了放射影像学检查（CT和MRI）。
本研究共纳入10例TBE患者。男女比例为1.5:1，平均年龄为45.1岁。半数患者临床表现严重。头颅CT扫描和MRI未发现任何异常，但最严重的中枢神经系统感染（脑膜脑脊髓炎）患者除外。80%的患者血沉和CRP平均值略有升高（分别为29.6mm/1小时和20.1mg/L），不过升高幅度几乎可忽略不计。脑脊液中白细胞平均数量为171×10⁶/L，脑脊液蛋白平均值为1.1g/L。无死亡病例。
由于其他中枢神经系统感染与TBE有相似的临床表现和脑脊液检查结果，因此TBE的血清学分析应纳入常规诊断实践。
