Peng Fenfen, Sun Lingzhi, Chen Ting, Zhu Yan, Zhou Weidong, Li Peilin, Chen Yihua, Zhuang Yiyi, Huang Qianyin, Long Haibo
Department of Nephrology, Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China.
BMC Nephrol. 2020 Feb 14;21(1):51. doi: 10.1186/s12882-020-1707-1.
Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients.
We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality.
The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07-2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10-3.69, p = 0.023 respectively].
Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality.
白蛋白球蛋白比值（AGR）是一项基于血清白蛋白和非白蛋白蛋白的指标，已被证明是恶性肿瘤患者死亡率的预测指标。本研究旨在评估AGR对腹膜透析（PD）患者的预后价值。
我们回顾性分析了2008年1月1日至2017年12月31日在本中心的602例新发PD患者，并对他们进行随访直至2018年12月31日。应用Kaplan-Meier曲线和多变量Cox回归模型分析AGR与全因死亡率和心血管死亡率之间的关联。
中位随访时间为32.17（四分位间距 = 32.80）个月。随访期间，131例（21.8%）患者死亡，其中57例（43.5%）死于心血管疾病。Kaplan-Meier曲线显示，AGR > 1.26的患者生存率高于AGR≤1.25的患者（p < 0.001）。在调整潜在混杂因素后，较低的AGR水平与全因死亡率和心血管死亡率增加显著相关[风险比（HR）：1.57，95%置信区间（CI）：1.07 - 2.32，p = 0.022；HR：2.01，95%CI：1.10 - 3.69，p = 0.023]。
AGR水平低的患者全因死亡率和心血管死亡率增加。AGR可能是识别有心血管疾病和全因死亡风险的PD患者的有用指标。
