Hamori C J, Vreman H J, Stevenson D K
Department of Pediatrics, Stanford University School of Medicine, CA 94305.
Res Commun Chem Pathol Pharmacol. 1988 Oct;62(1):41-8.
We studied the effect of zinc mesoporphyrin on the CO excretion rate (VeCO) and liver heme oxygenase activity of adult rats. A subcutaneous dose of 4 mumol/kg significantly lowered the VeCO between 4 and 12 hours after injection. The liver heme oxygenase activity of treated animals was significantly lower 12 hours after treatment. These findings demonstrate that zinc mesoporphyrin is a potent inhibitor of in vivo total bilirubin production, as measured by the VeCO.
我们研究了锌卟啉对成年大鼠一氧化碳排出率（VeCO）和肝脏血红素加氧酶活性的影响。皮下注射剂量为4 μmol/kg时，在注射后4至12小时显著降低了VeCO。治疗后12小时，接受治疗动物的肝脏血红素加氧酶活性显著降低。这些发现表明，通过VeCO测量，锌卟啉是体内总胆红素产生的有效抑制剂。
