Ammar H O, Salama H A
Pharmazie. 1977 Jan;32(1):34-5.
An interaction between thiamine hydrochloride and DL-alpha-lipoic acid in aqueous solution was depicted. Evidence is presented through spectrophotometric as well as vapour pressure measurements to show that thiamine hydrochloride and DL-alpha-lipoic acid form a single 1:1 complex. The stability constant and the molar extinction coefficient of the complex (at 244 nm) were determined at 25 degrees C and found to be 3.1-10(4) and 970, respectively. Vapour pressure measurements at 60 degrees C reveal that more or less complete dissociation of the complete takes place at this temperature.
描述了盐酸硫胺素与DL-α-硫辛酸在水溶液中的相互作用。通过分光光度法和蒸气压测量提供的证据表明，盐酸硫胺素与DL-α-硫辛酸形成单一的1:1络合物。在25℃下测定了该络合物的稳定常数和摩尔消光系数（在244nm处），分别为3.1×10⁴和970。60℃下的蒸气压测量表明，在此温度下该络合物或多或少会完全解离。
