Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan.
Department of Biochemistry, University of Karachi, Karachi, Pakistan.
Arch Virol. 2020 Apr;165(4):967-972. doi: 10.1007/s00705-020-04551-4. Epub 2020 Feb 14.
In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.
在巴基斯坦，艾滋病毒的情况已从爆发演变为集中流行，病毒现已蔓延到低风险人群。此外，该国不同地区还出现了几起新的艾滋病毒疫情。在巴基斯坦，HIV-1 亚型 A 一直是主要的流行亚型；然而，随着疫情的发展，观察到出现了几种新的亚型和重组形式。在这里，我们报告了首例在一名艾滋病毒感染者中出现的未分配、复杂重组形式以及病毒学失败的病例，并对其进行了遗传分析。序列分析表明，这种重组形式具有多种耐药性，对一种以上类别的抗逆转录病毒药物都具有耐药性突变。
