Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK.
Dig Dis Sci. 2020 Jun;65(6):1600-1607. doi: 10.1007/s10620-020-06127-3.
Although short- and medium-term outcomes after liver transplantation for alcohol-related liver disease (ARLD) are generally excellent and similar to outcomes for transplantation for other indications, a return to alcohol consumption commonly occurs even though rates of alcohol consumption after transplantation for ARLD are comparable to those seen in other indications. Transplant recipients should be questioned about alcohol use post-transplantation and, where appropriate, monitored; those drinking significant amounts should be offered treatment with the help of a multi-disciplinary team. Although short-term significant alcohol use is associated with an increased risk of non-compliance and rejection, medium-term outcomes are similar to other groups. Patients transplanted for ARLD have a greater risk of some de novo malignancies, especially of the lung and the upper GI tract. More work is required both to identify those at risk of a return to destructive patterns of alcohol use at an early stage and to develop effective treatments aimed at reaching and maintaining abstinence.
尽管肝移植治疗酒精性肝病（ALD）的短期和中期效果通常非常好，与其他适应证的移植效果相似，但即使在ALD 患者中，饮酒率与其他适应证相似，但仍常出现复饮现象。肝移植受者在移植后应被询问饮酒情况，如有必要，应进行监测；对于大量饮酒者，应在多学科团队的帮助下提供治疗。尽管短期内大量饮酒与不遵医嘱和排斥反应的风险增加有关，但中期结果与其他组相似。ALD 患者发生某些新发性恶性肿瘤的风险更高，尤其是肺部和上消化道。需要进一步研究，以早期识别那些有复饮风险的患者，并开发针对达到和维持戒酒的有效治疗方法。
