IL-21 在肿瘤微环境中的信号传导。
IL-21 Signaling in the Tumor Microenvironment.
机构信息
IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France.
出版信息
Adv Exp Med Biol. 2020;1240:73-82. doi: 10.1007/978-3-030-38315-2_6.
IL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity activities. It is a potent stimulator of T and natural killer cell-mediated antitumor immunity but also has pro-inflammatory functions in many tissues and is involved in oncogenesis. It is important to understand IL-21 biology in these different situations to ensure the maximal benefit of therapeutic strategies targeting this cytokine. This chapter summarizes IL-21 characteristics and signaling, its role in immune system components, and its use in cancer immunotherapies.
白细胞介素 21（IL-21）是一种由自然杀伤（NK）细胞和 T 细胞产生的免疫调节细胞因子，在免疫和非免疫细胞中具有多种作用。IL-21 可以调节先天和特异性免疫活性。它是 T 细胞和自然杀伤细胞介导的抗肿瘤免疫的有效刺激物，但在许多组织中也具有促炎功能，并参与肿瘤发生。了解这种细胞因子在不同情况下的生物学特性对于确保针对这种细胞因子的治疗策略的最大获益非常重要。本章总结了白细胞介素 21 的特征和信号转导、在免疫系统成分中的作用以及在癌症免疫治疗中的应用。
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