Kithier K, Samal B, Cejka J, Whitcomb M P, Mood D W
Department of Pathology, Wayne State University School of Medicine, Detroit, Mich.
Tumour Biol. 1988;9(6):307-14. doi: 10.1159/000217577.
Pancreatic oncofetal antigen (POA) and carcinoembryonic antigen (CEA) were determined in plasma of 195 patients with breast cancer and 90 patients with colon carcinoma. Increased levels of POA and CEA were seen in 19.0 and 25.6% of patients with breast cancer, respectively. Some but not all patients showed an increase in both markers. The incidence of abnormal concentrations of POA and CEA increased with the progress of the disease. POA appears to be a useful marker in breast cancer, especially in patients who have normal CEA levels. On the other hand, colon carcinoma patients showed increased POA concentrations considerably less frequently than CEA levels.
对195例乳腺癌患者和90例结肠癌患者的血浆进行了胰腺癌胚抗原（POA）和癌胚抗原（CEA）检测。乳腺癌患者中POA和CEA水平升高的比例分别为19.0%和25.6%。部分而非全部患者两种标志物均升高。POA和CEA异常浓度的发生率随疾病进展而增加。POA似乎是乳腺癌的一个有用标志物，尤其是在CEA水平正常的患者中。另一方面，结肠癌患者POA浓度升高的频率远低于CEA水平。
