Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Trends Immunol. 2020 Mar;41(3):187-189. doi: 10.1016/j.it.2020.01.008. Epub 2020 Feb 12.
To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8 T cell function and might be targeted to overcome incidence of infections.
为了控制 SLE 患者自身反应性 T 细胞，使用了免疫抑制方案，这会增加对细菌和病毒感染的易感性。最近，Katsuyama 等人表明，CD38/NAD/Sirtuin1/EZH2 轴降低了细胞毒性 CD8 T 细胞的功能，可能成为克服感染发生率的靶点。
