米诺环素：关注耐药机制、抗菌活性和临床疗效——回到未来。
Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future.
机构信息
Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran; Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
出版信息
J Glob Antimicrob Resist. 2020 Sep;22:161-174. doi: 10.1016/j.jgar.2020.01.022. Epub 2020 Feb 12.
OBJECTIVES
The increasing crisis regarding multidrug-resistant (MDR) and extensively drug-resistant microorganisms leads to appealing therapeutic options.
METHODS
During the last 30 years, minocycline, a wide-spectrum antimicrobial agent, has been effective against MDR Gram-positive and Gram-negative bacterial infections. As with other tetracyclines, the mechanism of action of minocycline involves attaching to the bacterial 30S ribosomal subunit and preventing protein synthesis.
RESULTS
This antimicrobial agent has been approved for the treatment of acne vulgaris, some sexually transmitted diseases and rheumatoid arthritis. Although many reports have been published, there remains limited information regarding the prevalence, mechanism of resistance and clinical effectiveness of minocycline.
CONCLUSION
Thus, we summarize here the currently available data concerning pharmacokinetics and pharmacodynamics, mechanism of action and resistance, antibacterial activity and clinical effectiveness of minocycline.
目的
越来越多的多药耐药（MDR）和广泛耐药微生物的危机导致了有吸引力的治疗选择。
方法
在过去的 30 年中，米诺环素是一种广谱抗菌药物，对 MDR 革兰氏阳性和革兰氏阴性细菌感染有效。与其他四环素类药物一样，米诺环素的作用机制涉及与细菌的 30S 核糖体亚基结合并阻止蛋白质合成。
结果
这种抗菌药物已被批准用于治疗寻常痤疮、一些性传播疾病和类风湿关节炎。尽管已经发表了许多报告，但关于米诺环素的流行程度、耐药机制和临床疗效的信息仍然有限。
结论
因此，我们在这里总结了关于米诺环素的药代动力学和药效学、作用机制和耐药性、抗菌活性和临床疗效的现有数据。
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