绝经早期与外周动脉粥样硬化斑块体积增加和进展有关。

Early onset of menopause is associated with increased peripheral atherosclerotic plaque volume and progression.

机构信息

Department of Internal Medicine III (Cardiology and Angiology), Medical University of Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria.

出版信息

Atherosclerosis. 2020 Mar;297:25-31. doi: 10.1016/j.atherosclerosis.2020.01.023. Epub 2020 Jan 31.

DOI:10.1016/j.atherosclerosis.2020.01.023

PMID:32062136

Abstract

BACKGROUND AND AIMS

Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV).

METHODS

Postmenopausal women with at least one cardiovascular risk factor (CVRF) but without established CVD were included. Quantification of PV was performed in peripheral arteries using a three - dimensional (3D) ultrasound (US) technique. Follow-up examination to assess PV progression was performed after 19 (±8) months.

RESULTS

110 consecutive postmenopausal women (mean age 65.5) were included. Females with an earlier onset of MP (<45 years) had a significantly higher PV than those with an intermediate (45-52 years) or later onset of menopause (>52 years), irrespective of other CVRF (244 mm³ vs. 193 mm³ vs. 73 mm³, respectively, p = 0.023). In addition, women with an earlier onset of MP had a higher PV progression compared to women with an intermediate or late onset (40 mm³ vs. 35 mm³ vs. 8.5 mm³; p = 0.002, respectively). Moreover, these results were confirmed in multivariate regression, where only onset of MP (OR 0.88; 95%CI 0.81-0.96; p = 0.004) and age (OR 1.06; 95%CI 1.08-1.13; p = 0.025) were significant predictors for a higher atherosclerotic progression.

CONCLUSIONS

An earlier onset of MP was associated with an increase in atherosclerotic PV and accelerated progression, independent of other CVRF.

摘要

背景与目的

心血管疾病（CVD）是西方国家的主要死亡原因。女性特有的一个风险因素是绝经状态。本研究旨在分析绝经（MP）的开始对动脉粥样硬化斑块体积（PV）程度和进展的影响。

方法

纳入至少有一个心血管风险因素（CVRF）但没有明确的 CVD 的绝经后女性。使用三维（3D）超声（US）技术对周围动脉的 PV 进行定量。在 19（±8）个月后进行随访检查以评估 PV 进展。

结果

纳入了 110 名连续的绝经后女性（平均年龄 65.5 岁）。MP 早期发作（<45 岁）的女性 PV 明显高于中期（45-52 岁）或晚期（>52 岁）的女性，无论其他 CVRF 如何（分别为 244mm³、193mm³、73mm³，p=0.023）。此外，MP 早期发作的女性与中期或晚期发作的女性相比，PV 进展更高（40mm³、35mm³、8.5mm³；p=0.002）。此外，多变量回归证实了这些结果，其中只有 MP 发作（OR 0.88；95%CI 0.81-0.96；p=0.004）和年龄（OR 1.06；95%CI 1.08-1.13；p=0.025）是预测更高动脉粥样硬化进展的显著因素。