Glahn B E, Braendstrup O, Olesen H P
Department of Urology, Glostrup Hospital, Denmark.
Scand J Urol Nephrol. 1988;22(2):93-9. doi: 10.1080/00365599.1988.11690392.
A previous study demonstrated a strong but short-lasting suction through the catheter eyes by a hydro-dynamically generated negative pressure fluctuation terminating bladder evacuation in some frequently occurring circumstances of indwelling catheter drainage. This report regards the biological effect. Fifteen successive evacuations on such drainage conditions in each of 4 anesthetized pigs were followed by cystectomy and histological examination. All bladders presented small swollen areas, histologically showing localized mucosal elevations dominated by edema of lamina propria and submucosa, occasionally with urothelial thinning or defects. Drainage with suction prevented in 3 animals caused normal bladders. The changes were similar to those following hydro-statical suction and much like those of the "polypoid cystitis" so commonly occurring with indwelling catheters. This suggests both types of suction by ordinary drainage as a major pathogenetic factor in the latter condition. The clinical significance and the occurrence during regimes of straight drainage or intermittent clamping are discussed.
先前的一项研究表明，在留置导管引流的一些常见情况下，通过流体动力学产生的负压波动会在导管眼处产生强烈但持续时间短的吸力，从而终止膀胱排空。本报告关注其生物学效应。对4只麻醉猪在这种引流条件下进行了连续15次排空，随后进行膀胱切除术和组织学检查。所有膀胱均出现小的肿胀区域，组织学显示局部黏膜隆起，以固有层和黏膜下层水肿为主，偶尔伴有尿路上皮变薄或缺损。在3只动物中阻止负压吸引引流后膀胱正常。这些变化与静水负压吸引后的变化相似，很像留置导管时常见的“息肉样膀胱炎”。这表明普通引流的两种吸引方式都是后者发病的主要致病因素。文中讨论了其临床意义以及在持续引流或间歇性夹闭期间的发生情况。
