Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Cortex. 2020 May;126:73-82. doi: 10.1016/j.cortex.2019.12.030. Epub 2020 Feb 10.
We studied 156 individuals with acute, right hemisphere ischemic stroke on a battery of hemispatial neglect tests to distinguish between viewer-centered and stimulus-centered neglect and MRI diffusion weighted imaging. We identified the relative contributions of age, total lesion volume, and damage to subcortical and cortical grey matter regions as well as white matter tracts to both the severity and presence of significant viewer-centered and stimulus-centered neglect, using multivariable regression tests. We found that age, volume of lesion, and percent damage to the regions of interest were each independently associated with the severity of viewer-centered neglect (r = .31; p < .0001). However, only age (t = 3.20; p = .002) and percent damage to the angular gyrus (t = 2.63, p = .010), a dorsal stream area, predicted severity of viewer-centered neglect independently of the other variables. The same variables predicted the presence of significant viewer-centered neglect. In contrast, these variables did not significantly predict the severity of stimulus-centered neglect. However, we found that percent damage to ventral stream regions of interest (middle temporal gyrus, inferior temporal gyrus, fusiform gyrus, inferior frontal occipital gyrus, sagittal stratum, along with total infarct volume were associated with the presence of significant stimulus-centered neglect (pseudo r = .70, p < .0004). Only percent damage to right inferior temporal gyrus predicted stimulus-centered neglect independently of the other variables (p = .018).
我们研究了 156 名急性右脑半球缺血性中风患者，对其进行了一系列偏侧忽略测试，以区分以观察者为中心和以刺激为中心的忽略，并进行磁共振弥散加权成像。我们使用多变量回归测试，确定年龄、总病变体积以及皮质下和皮质灰质区域以及白质束损伤对以观察者为中心和以刺激为中心的严重程度和显著忽略的相对贡献。我们发现，年龄、病变体积和感兴趣区域的损伤百分比均与以观察者为中心的忽略的严重程度独立相关（r =.31；p <.0001）。然而，只有年龄（t = 3.20；p =.002）和角回（t = 2.63，p =.010）的损伤百分比，即背侧流区域，可独立于其他变量预测以观察者为中心的忽略的严重程度。同样的变量预测了以观察者为中心的忽略的存在。相比之下，这些变量并不能显著预测以刺激为中心的忽略的严重程度。然而，我们发现，感兴趣的腹侧流区域（颞中回、颞下回、梭状回、下额枕叶回、矢状层以及总梗死体积）的损伤百分比与以刺激为中心的显著忽略有关（伪 r =.70，p <.0004）。只有右侧颞下回的损伤百分比可独立于其他变量预测以刺激为中心的忽略（p =.018）。
