Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven - University of Leuven, Herestraat 49, O&N2, PB 923, 3000, Leuven, Belgium.
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Polo Annunziata, viale Annunziata, 98168, Messina, Italy.
Anal Bioanal Chem. 2020 Apr;412(11):2537-2544. doi: 10.1007/s00216-020-02478-y. Epub 2020 Feb 15.
Most of the reported methods for the analysis of volatile methylsiloxanes focus on their environmental fate or possible health effects, aiming at trace level analysis by using direct injection gas chromatography. However, system contamination as carry over and side reactions at the injector are commonly reported in those cases. In this article, we explore the use of headspace gas chromatography combined with the total vaporization technique as an alternative to avoid such issues for the analysis of linear (L2-L5) and cyclic (D3-D5) volatile methylsiloxanes. The proposed method showed good linearity with R values higher than 0.9961 and no significant contribution (α = 0.05) of the intercept. The limit of detection was always below 0.11 μg/vial (0.0025% m/m). Finally, the method was applied to real samples like an adhesive remover, hair oil, shampoo, and cream. After simple sample pretreatment, recoveries higher than 86% were achieved. Graphical abstract.
大多数报道的挥发性甲基硅氧烷分析方法都侧重于其环境命运或可能的健康影响，旨在通过直接进样气相色谱法进行痕量分析。然而，在这些情况下，通常会报道在进样器处发生的携带污染和副反应等问题。在本文中，我们探索了使用顶空气相色谱法结合总蒸发技术作为替代方法，以避免分析线性（L2-L5）和环状（D3-D5）挥发性甲基硅氧烷时出现此类问题。所提出的方法表现出良好的线性，相关系数（R 值）高于 0.9961，截距的贡献不显著（α=0.05）。检测限始终低于 0.11μg/小瓶（0.0025%m/m）。最后，该方法应用于实际样品，如除胶剂、发油、洗发水和面霜。经过简单的样品预处理，回收率高于 86%。
