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基于聚类分析的痴呆早期识别与医疗管理项目参与者的临床特征及相关支持措施的效果

Clinical characteristics of participants enrolled in an early identification and healthcare management program for dementia based on cluster analysis and the effectiveness of associated support efforts.

作者信息

Kawakita Hitomi, Ogawa Masahiro, Matsumoto Keiko, Kawakita Yuichiro, Hara Mayumi, Koyama Yumi, Fujita Yoshinari, Oshita Masanori, Mori Toshio, Toichi Motomi, Takechi Hajime

机构信息

Faculty of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The Central Uji Area Comprehensive Support Center, Uji, Kyoto, Japan.

出版信息

Int Psychogeriatr. 2020 May;32(5):573-583. doi: 10.1017/S104161021900125X. Epub 2020 Feb 17.

Abstract

OBJECTIVE

Although early identification and management services for dementia have become more widespread, their efficacy and the clinical characteristics of service have yet to be fully evaluated. Therefore, the objective of this study is to clarify these issues.

MEASUREMENTS

The subjects were 164 Japanese users of an early identification and management program for dementia, known as the Initial-phase Intensive Support Team (IPIST), between 2013 and 2015. Nonhierarchical cluster analysis was used to derive subgroups based on cognitive status and ability in activities of daily living (ADL) and behavioral and psychological symptoms of dementia (BPSD). One-way analysis of variance was performed to evaluate differences among the groups derived by the cluster analysis. A paired t test was used to assess how the clinical status of the groups changed between baseline and follow-up.

RESULTS

Four groups were identified by cluster analysis, i.e. a mild group, a moderate group, a BPSD group with moderate cognitive impairment and severe BPSD, and a severe group with severe cognitive impairment and severe BPSD. Although there were no significant improvements in cognitive impairment or ADL in any group, significant improvements were found in BPSD in the BPSD and severe BPSD groups. Caregiver burden was significantly lessened in all groups. Clinical diagnosis and long-term care insurance service utilization rates were significantly improved overall.

CONCLUSION

The users of IPIST were classified into four subgroups based on their clinical characteristics. The IPIST program could improve the quality of life of people with dementia and their caregivers.

摘要

目的

尽管针对痴呆症的早期识别和管理服务已更为普及,但其疗效及服务的临床特征仍有待全面评估。因此,本研究的目的是阐明这些问题。

测量方法

研究对象为2013年至2015年间164名参与痴呆症早期识别与管理项目(即初始阶段强化支持团队,IPIST)的日本使用者。采用非层次聚类分析,根据认知状态、日常生活活动能力(ADL)以及痴呆症的行为和心理症状(BPSD)划分亚组。进行单因素方差分析以评估聚类分析得出的各组之间的差异。采用配对t检验评估各组临床状态在基线和随访之间的变化情况。

结果

聚类分析确定了四组,即轻度组、中度组、伴有中度认知障碍和重度BPSD的BPSD组以及伴有重度认知障碍和重度BPSD的重度组。尽管任何组的认知障碍或ADL均无显著改善,但BPSD组和重度BPSD组的BPSD有显著改善。所有组的照料者负担均显著减轻。总体上临床诊断和长期护理保险服务利用率显著提高。

结论

IPIST的使用者根据其临床特征被分为四个亚组。IPIST项目可以改善痴呆症患者及其照料者的生活质量。

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