Pekarek Brandon T, Hunt Patrick J, Arenkiel Benjamin R
Genetics and Genomics Program, Baylor College of Medicine, Houston, TX, United States.
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
Front Neurosci. 2020 Jan 29;14:30. doi: 10.3389/fnins.2020.00030. eCollection 2020.
An essential characteristic of nervous systems is their capacity to reshape functional connectivity in response to physiological and environmental cues. Endogenous signals, including neuropeptides, governs nervous system plasticity. Particularly, oxytocin has been recognized for its role in mediating activity-dependent circuit changes. These oxytocin-dependent changes occur at the synaptic level and consequently shape the cellular composition of circuits. Here we discuss recent advances that illustrate how oxytocin functions to reshape neural circuitry in response to environmental changes. Excitingly, recent findings pave the way for promising therapeutic applications of oxytocin to treat neurodevelopmental and neuropsychiatric diseases.
神经系统的一个基本特征是其能够根据生理和环境线索重塑功能连接。包括神经肽在内的内源性信号控制着神经系统的可塑性。特别是，催产素因其在介导依赖活动的回路变化中的作用而受到认可。这些依赖催产素的变化发生在突触水平，从而塑造了回路的细胞组成。在这里，我们讨论了最近的进展，这些进展说明了催产素如何响应环境变化来重塑神经回路。令人兴奋的是，最近的发现为催产素治疗神经发育和神经精神疾病的有前景的治疗应用铺平了道路。
