Barr James, Chudasama Dimple, Rice Alex, Karteris Emmanouil, Anikin Vladimir
Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield UB9 6JH, UK.
Department of Biomedical Science, Brunel University, London UB8 3PH, UK.
Mol Clin Oncol. 2020 Mar;12(3):191-195. doi: 10.3892/mco.2020.1981. Epub 2020 Jan 21.
Circulating tumour cells (CTCs) are cancer cells of epithelial origin that are present in peripheral blood samples. ScreenCell detection of CTCs and the association with long term survival in non-small cell lung cancer (NSCLC) patients was evaluated in the present study. A total of 33 patients undergoing surgical resection for NSCLC were recruited. Patients were followed up for 5-years post-operatively. Pre-operative patient bloods samples were processed using ScreenCell. CTCs were detected in 26 (79%) patients. In patients who were positive for CTCs, a total of 9 (35%) patients succumbed to the disease, whereas in patients negative for CTCs, a total of 4 (57%) patients succumbed to the disease (P=0.29). No association was identified between positive CTCs and poorer survival (Chi-squared 1.47, P=0.23; hazard ratio, 0.42; 95% confidence interval: 0.1-1.7). The presence of CTCs detected with ScreenCell does not influence prognosis in patients with NSCLC that was operated on. The high rate of CTC detection is encouraging in supporting this technology to aid early lung cancer diagnosis.
循环肿瘤细胞（CTCs）是存在于外周血样本中的上皮源性癌细胞。本研究评估了ScreenCell检测CTCs及其与非小细胞肺癌（NSCLC）患者长期生存的相关性。共招募了33例接受NSCLC手术切除的患者。对患者进行术后5年的随访。术前患者血液样本采用ScreenCell进行处理。26例（79%）患者检测到CTCs。在CTCs阳性的患者中，共有9例（35%）患者死于该疾病，而在CTCs阴性的患者中，共有4例（57%）患者死于该疾病（P = 0.29）。未发现CTCs阳性与较差生存率之间存在关联（卡方值1.47，P = 0.23；风险比，0.42；95%置信区间：0.1 - 1.7）。ScreenCell检测到的CTCs的存在并不影响接受手术的NSCLC患者的预后。CTCs的高检测率对于支持该技术辅助早期肺癌诊断是令人鼓舞的。
