铁催化醇的借氢β-(sp)甲基化反应

Polidano Kurt, Williams Jonathan M J, Morrill Louis C

Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, U.K.

Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, U.K.

ACS Catal. 2019 Sep 6;9(9):8575-8580. doi: 10.1021/acscatal.9b02461. Epub 2019 Aug 21.

Herein we report the iron-catalyzed (sp)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo (sp)-methylation in good isolated yields (24 examples, 65% average yield).

在此，我们报道了以甲醇作为C1结构单元，铁催化的伯醇的（sp）-甲基化反应。这种借氢方法使用了一种定义明确的、易于操作的（环戊二烯酮）铁（0）羰基配合物作为预催化剂（5 mol%），能够使多种取代的2-芳基乙醇以良好的分离产率进行（sp）-甲基化反应（24个实例，平均产率65%）。