Solmaz Abdullah, Demir Abit, Gümüş Hüseyin, Aksoy Mustafa, Solmaz Filiz
Pediatrics, Harran University, Şanlıurfa, TUR.
Dermatology, Harran University, Şanlıurfa, TUR.
Cureus. 2020 Jan 9;12(1):e6607. doi: 10.7759/cureus.6607.
The purpose of this study was to compare neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of patients with measles within the healthy control group and then determine the utility of these parameters for determination of inflammatory situation in patients with measles.
A total of 51 pediatric patients who had visited Harran University Medical Faculty Pediatrics Clinic between June 2018 and May 2019 and who had been diagnosed with measles after anamnesis, clinical, and serological evaluations were included our study; 49 healthy children who visited our clinic for various reasons and had taken hemogram tests were also added to our study as the control group.
NLR and PLR values were observed higher than the control group for patients diagnosed with measles; however, the difference between the two groups was not statistically significant (p values 0.515 and 0.796, respectively). When MPV values of patients diagnosed with measles and control groups were compared, it was determined that MPV value was statistically lower in patients diagnosed with measles (p: 0.001).
Based on the parameters obtained through our study, it can be said that NLR and PLR are not suitable parameters for proving inflammation in patients with measles but MPV can be used as a convenient parameter for that purpose. However, prospective studies conducted with more patients are needed in this respect.
本研究旨在比较麻疹患者与健康对照组中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)及平均血小板体积(MPV)值,进而确定这些参数在判定麻疹患者炎症状况方面的效用。
纳入2018年6月至2019年5月期间前往哈兰大学医学院儿科门诊就诊、经问诊、临床及血清学评估后确诊为麻疹的51例儿科患者;另外,将因各种原因前来我院门诊就诊并进行血常规检查的49例健康儿童作为对照组纳入本研究。
确诊为麻疹的患者NLR和PLR值高于对照组;然而,两组间差异无统计学意义(p值分别为0.515和0.796)。比较确诊为麻疹的患者与对照组的MPV值,发现确诊为麻疹的患者MPV值在统计学上较低(p:0.001)。
基于本研究获得的参数,可以说NLR和PLR并非证明麻疹患者炎症的合适参数,但MPV可作为用于此目的的便捷参数。然而,在这方面需要对更多患者进行前瞻性研究。