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基于 DNA-MOF 杂化体的荧光传感器的最新进展。

Recent advances in fluorescence sensors based on DNA-MOF hybrids.

机构信息

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China.

出版信息

Luminescence. 2020 Jun;35(4):440-446. doi: 10.1002/bio.3790. Epub 2020 Feb 16.

DOI:10.1002/bio.3790
PMID:32064758
Abstract

In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases.

摘要

在这篇综述中，报道了基于 DNA 和金属-有机骨架杂化材料的荧光传感器在核酸、金属离子和氨基酸检测方面的最新进展。主要检测机制取决于 MOFs 对不同 DNA 结构（单链 DNA、双链 DNA）的不同吸附能力，从而改变探针 DNA 的荧光强度。这些结果可能为研究它们在材料科学和某些相关疾病的临床诊断中的潜在应用开辟了道路。

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