Private practice, Milan, Italy.
Universidad Europea Madrid, Madrid, Spain.
J Biol Regul Homeost Agents. 2020 Jan-Feb;34(1 Suppl. 1):109-113. DENTAL SUPPLEMENT.
Control of bleeding after oral surgery is mandatory in patients taking anticoagulants. There are different haemostatic measures to prevent post-surgical bleeding. The aim of the present paper is to study the use of a haemostatic agent, calcium sulphate (CaS) (P30, Ghimas, Bologna, Italy) for controlling post-surgical bleeding in a group of patients treated with warfarin therapy for thromboembolic states. Twenty teeth (12 mandibular molars, 8 maxillary molars) in 20 patients (14 male and 6 females) with a mean age of 54.3 years (±10.3 years) were included in the study. The patients were divided into 2 groups; in the study group of 10 patients calcium sulphate was used in layers to fill the socket after extraction, while for the 10 patients in the control group put a gauze with tranexamic acid was put in the extraction site immediately after extraction, and half an hour after extraction. The outcome was bleeding in subsequent days. Bleeding at post-operative day 1 was significant in 5 patients of the control group, however, in the study group treated with calcium sulfate there was no bleeding in any patient (p value 0.0055). CaS demonstrated to be a good haemostatic agent for controlling bleeding after oral surgery in patients taking anticoagulants.
在接受抗凝治疗的患者中，口腔手术后控制出血是强制性的。有不同的止血措施可以预防手术后出血。本文的目的是研究在接受华法林治疗血栓栓塞状态的患者中使用止血剂硫酸钙（CaS）（P30，Ghimas，博洛尼亚，意大利）控制手术后出血的情况。研究纳入了 20 名患者（14 名男性和 6 名女性）的 20 颗牙齿（12 颗下颌磨牙，8 颗上颌磨牙），平均年龄为 54.3 岁（±10.3 岁）。患者被分为两组；在研究组的 10 名患者中，在拔牙后分层使用硫酸钙填充牙槽窝，而在对照组的 10 名患者中，在拔牙后立即在拔牙部位放置含有氨甲环酸的纱布，拔牙后半小时。结果是随后几天的出血情况。对照组的 5 名患者在术后第 1 天出现明显出血，而在接受硫酸钙治疗的研究组中，没有患者出现出血（p 值 0.0055）。CaS 被证明是一种在接受抗凝治疗的患者中控制口腔手术后出血的良好止血剂。
