Department of Public Health Science, LANDSAM, Norwegian University of Life Sciences, Ås, Norway.
Department of Health & Inequality, Norwegian Institute of Public Health, Oslo, Norway.
Scand J Gastroenterol. 2020 Mar;55(3):272-278. doi: 10.1080/00365521.2020.1726446. Epub 2020 Feb 17.
Adverse birth outcomes are more frequent among mothers with inflammatory bowel diseases (IBDs) than non-IBD mothers. In recent studies, air pollution, such as high concentrations of nitrogen dioxide (NO), is reckoned as a risk factor for preterm birth in the general population. In this study, we investigated whether IBD mothers are at higher risk of preterm birth when exposed to NO compared to non-IBD mothers. We used information from the Norwegian Mother, Father and Child Cohort Study (MoBa). The pregnancy cohort was linked to the Norwegian Medical Birth Registry and air-pollution exposure data available from a subset of the study cohort. The relevant outcome in this study was preterm birth. A total of 16,170 non-IBD and 92 IBD mothers were included in the study. The mean exposure of NO during the pregnancy was similar for IBD and non-IBD mothers, 13.7 (6.9) μg/m and 13.6 (4.2) μg/m, respectively.IBD mothers with higher exposure of NO in the second and third trimester were at significant risk of preterm birth compared to non-IBD mothers [OR = 1.28 (CI 95%: 1.04-1.59) and OR = 1.23 (95% CI: 1.06-1.43), respectively]. The mean NO exposure was significantly higher in IBD mothers with preterm birth than in IBD mothers who delivered at term, at 19.58 (1.57) μg/m and 12.89 (6.37) μg/m, respectively. NO exposure influenced the risk of preterm birth in IBD mothers. Higher risk of preterm birth in IBD was associated with higher exposure of NO, suggesting vulnerability of preterm birth in IBD when exposed to NO.
不良出生结局在患有炎症性肠病（IBD）的母亲中比非 IBD 母亲更为常见。在最近的研究中，空气污染，如二氧化氮（NO）浓度较高，被认为是普通人群早产的一个危险因素。在这项研究中，我们调查了与非 IBD 母亲相比，IBD 母亲在接触 NO 时是否有更高的早产风险。我们使用了来自挪威母亲、父亲和儿童队列研究（MoBa）的信息。该妊娠队列与挪威医学出生登记处相关联，并且可以从研究队列的一个子集获得空气污染暴露数据。本研究中的相关结局是早产。共有 16170 名非 IBD 和 92 名 IBD 母亲纳入了研究。IBD 和非 IBD 母亲在怀孕期间的 NO 暴露平均值相似，分别为 13.7（6.9）μg/m 和 13.6（4.2）μg/m。在第二和第三个孕期 NO 暴露较高的 IBD 母亲与非 IBD 母亲相比，早产的风险显著增加[OR=1.28（95%CI：1.04-1.59）和 OR=1.23（95%CI：1.06-1.43）]。与足月分娩的 IBD 母亲相比，NO 暴露较高的 IBD 母亲早产的平均 NO 暴露明显更高，分别为 19.58（1.57）μg/m 和 12.89（6.37）μg/m。NO 暴露影响 IBD 母亲早产的风险。IBD 中早产风险增加与较高的 NO 暴露有关，这表明 IBD 中早产对 NO 暴露的敏感性增加。
