Vaish Institute of Pharmaceutical Education & Research, Rohtak, Haryana, India.
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India.
Curr Pharm Des. 2020;26(15):1650-1665. doi: 10.2174/1381612826666200217115211.
The synthetic heterocyclic compounds have their importance due to their wide applications in various fields of science. The heterocyclic compounds have been reported for their anticancer, antitubercular, insecticides, analeptics, analgesic, anti-bacterial, anti-viral, anti-fungal, and weedicidal activity. Researchers have tried various newer targets in search of better antimicrobials acting via novel mechanisms. Glucosamine-6-Phosphate synthase is an enzyme present in microbial cells. The inactivation of G-6-P synthase may serve as a novel approach to find better antimicrobials. The increasing demands development of newer and effective antimicrobial drugs has reported in search of newer techniques for the generation of new drugs. Hence, the molecular docking technique shall be explored to find or investigate the newer target finding the novel compounds which can be an active antimicrobial compound. The present review has focused on the reported heterocyclic compounds which have been evaluated for their antimicrobial potential using G-6-P synthase as a target. The results of in silico methods and in vitro methods have been compared and critically discussed.
合成杂环化合物因其在科学各个领域的广泛应用而具有重要意义。杂环化合物因其抗癌、抗结核、杀虫剂、苏醒剂、镇痛药、抗菌、抗病毒、抗真菌和除草活性而被报道。研究人员已经尝试了各种新的靶点，以寻找通过新机制发挥作用的更好的抗菌药物。葡萄糖-6-磷酸合酶是微生物细胞中存在的一种酶。G-6-P 合酶的失活可能成为寻找更好的抗菌药物的一种新方法。为了满足不断增长的需求，开发更新的、有效的抗菌药物的需求已经出现，因此，人们报告了寻找新技术以生成新药的需求。因此，应当探索分子对接技术，以寻找或研究可以作为活性抗菌化合物的新型化合物的新型靶点。本综述重点介绍了已报道的杂环化合物，这些化合物已使用 G-6-P 合酶作为靶点进行了抗菌潜力评估。比较并批判性地讨论了基于计算机的方法和基于体外的方法的结果。
